Rat carotid artery dilation by PTCA balloon catheter induces neointima formation in presence of IEL rupture

Ciro Indolfi, Daniele Torella, Carmela Coppola, Eugenio Stabile, Giovanni Esposito, Antonio Curcio, Alfonso Pisani, Luigi Cavuto, Oreste Arcucci, Manuela Cireddu, Giancarlo Troncone, Massimo Chiariello

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The best animal angioplasty model is the porcine model, which is expensive and not available in all laboratories. The aim of this study was to describe a new rat model of angioplasty. An injury was induced with the use of a standard percutaneous transluminal coronary angioplasty (PTCA) 1.5-mm balloon catheter. The neointimal tissue, arterial dimensions, and the injury index were assessed following angioplasty. Ki-67 expression was detected to evaluate cell turnover after balloon angioplasty. In contrast with the standard Clowes model, a significant neointimal formation was detected only in the presence of ruptured internal elastic lamina (IEL). A positive correlation between the percentage of ruptured IEL and the amount of neointimal tissue was also demonstrated. The percentage of IEL fracture correlates with the proliferation index by anti-Ki-67 immunolabeling 7 and 14 days after the angioplasty. Significant arterial negative remodeling was observed following PTCA balloon dilation. In conclusion, our inexpensive animal model of restenosis after angioplasty may have great relevance toward a better understanding of the mechanisms and toward assessment of new therapeutical strategies for this phenomenon.

Original languageEnglish
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Issue number2 52-2
Publication statusPublished - 2002


  • Angioplasty
  • Restenosis

ASJC Scopus subject areas

  • Physiology


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