Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 440-443 |
| Number of pages | 4 |
| Journal | HIV Medicine |
| Volume | 18 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Jul 1 2017 |
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Keywords
- HIV
- HIV RNA
- birth weight
- pregnancy
- preterm delivery
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Rate, correlates and outcomes of repeat pregnancy in HIV-infected women. / Floridia, M.; Tamburrini, E.; Masuelli, G.; Martinelli, P.; Spinillo, A.; Liuzzi, G.; Vimercati, A.; Alberico, S.; Maccabruni, A.; Pinnetti, C.; Frisina, V.; Dalzero, S.; Ravizza, M.; Pregnancy, Italian Group for Surveillance of Antiretroviral Treatment in.
In: HIV Medicine, Vol. 18, No. 6, 01.07.2017, p. 440-443.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Rate, correlates and outcomes of repeat pregnancy in HIV-infected women
AU - Floridia, M.
AU - Tamburrini, E.
AU - Masuelli, G.
AU - Martinelli, P.
AU - Spinillo, A.
AU - Liuzzi, G.
AU - Vimercati, A.
AU - Alberico, S.
AU - Maccabruni, A.
AU - Pinnetti, C.
AU - Frisina, V.
AU - Dalzero, S.
AU - Ravizza, M.
AU - Pregnancy, Italian Group for Surveillance of Antiretroviral Treatment in
N1 - LR: 20170605; CI: (c) 2016; JID: 100897392; OTO: NOTNLM; 2016/09/21 00:00 [accepted]; 2016/12/22 06:00 [pubmed]; 2016/12/22 06:00 [medline]; 2016/12/22 06:00 [entrez]; ppublish
PY - 2017/7/1
Y1 - 2017/7/1
N2 - OBJECTIVES: The aim of the study was to assess the rate, determinants, and outcomes of repeat pregnancies in women with HIV infection. METHODS: Data from a national study of pregnant women with HIV infection were used. Main outcomes were preterm delivery, low birth weight, CD4 cell count and HIV plasma viral load. RESULTS: The rate of repeat pregnancy among 3007 women was 16.2%. Women with a repeat pregnancy were on average younger than those with a single pregnancy (median age 30 vs. 33 years, respectively), more recently diagnosed with HIV infection (median time since diagnosis 25 vs. 51 months, respectively), and more frequently of foreign origin [odds ratio (OR) 1.36; 95% confidence interval (CI) 1.10-1.68], diagnosed with HIV infection in the current pregnancy (OR: 1.69; 95% CI: 1.35-2.11), and at their first pregnancy (OR: 1.33; 95% CI: 1.06-1.66). In women with sequential pregnancies, compared with the first pregnancy, several outcomes showed a significant improvement in the second pregnancy, with a higher rate of antiretroviral treatment at conception (39.0 vs. 65.4%, respectively), better median maternal weight at the start of pregnancy (60 vs. 61 kg, respectively), a higher rate of end-of-pregnancy undetectable HIV RNA (60.7 vs. 71.6%, respectively), a higher median birth weight (2815 vs. 2885 g, respectively), lower rates of preterm delivery (23.0 vs. 17.7%, respectively) and of low birth weight (23.4 vs. 15.4%, respectively), and a higher median CD4 cell count (+47 cells/muL), with almost no clinical progression to Centers for Disease Control and Prevention stage C (CDC-C) HIV disease (0.3%). The second pregnancy was significantly more likely to end in voluntary termination than the first pregnancy (11.4 vs. 6.1%, respectively). CONCLUSIONS: Younger and foreign women were more likely to have a repeat pregnancy; in women with sequential pregnancies, the second pregnancy was characterized by a significant improvement in several outcomes, suggesting that women with HIV infection who desire multiple children may proceed safely and confidently with subsequent pregnancies.
AB - OBJECTIVES: The aim of the study was to assess the rate, determinants, and outcomes of repeat pregnancies in women with HIV infection. METHODS: Data from a national study of pregnant women with HIV infection were used. Main outcomes were preterm delivery, low birth weight, CD4 cell count and HIV plasma viral load. RESULTS: The rate of repeat pregnancy among 3007 women was 16.2%. Women with a repeat pregnancy were on average younger than those with a single pregnancy (median age 30 vs. 33 years, respectively), more recently diagnosed with HIV infection (median time since diagnosis 25 vs. 51 months, respectively), and more frequently of foreign origin [odds ratio (OR) 1.36; 95% confidence interval (CI) 1.10-1.68], diagnosed with HIV infection in the current pregnancy (OR: 1.69; 95% CI: 1.35-2.11), and at their first pregnancy (OR: 1.33; 95% CI: 1.06-1.66). In women with sequential pregnancies, compared with the first pregnancy, several outcomes showed a significant improvement in the second pregnancy, with a higher rate of antiretroviral treatment at conception (39.0 vs. 65.4%, respectively), better median maternal weight at the start of pregnancy (60 vs. 61 kg, respectively), a higher rate of end-of-pregnancy undetectable HIV RNA (60.7 vs. 71.6%, respectively), a higher median birth weight (2815 vs. 2885 g, respectively), lower rates of preterm delivery (23.0 vs. 17.7%, respectively) and of low birth weight (23.4 vs. 15.4%, respectively), and a higher median CD4 cell count (+47 cells/muL), with almost no clinical progression to Centers for Disease Control and Prevention stage C (CDC-C) HIV disease (0.3%). The second pregnancy was significantly more likely to end in voluntary termination than the first pregnancy (11.4 vs. 6.1%, respectively). CONCLUSIONS: Younger and foreign women were more likely to have a repeat pregnancy; in women with sequential pregnancies, the second pregnancy was characterized by a significant improvement in several outcomes, suggesting that women with HIV infection who desire multiple children may proceed safely and confidently with subsequent pregnancies.
KW - HIV
KW - HIV RNA
KW - birth weight
KW - pregnancy
KW - preterm delivery
U2 - 10.1111/hiv.12473 [doi]
DO - 10.1111/hiv.12473 [doi]
M3 - Article
VL - 18
SP - 440
EP - 443
JO - HIV Medicine
JF - HIV Medicine
SN - 1464-2662
IS - 6
ER -