Rate of desensitization to HL A antibodies in phytohaemagglutinin (PHA) stimulated lymphocytes

C. Rugarli, R. Scorza, M. G. Sabbadini

Research output: Contribution to journalArticlepeer-review

Abstract

Three trials were performed, employing peripheral blood lymphocytes from 2 donors and 3 typing antisera in which escape from sensitization to HL A antibodies was observed both in unstimulated and in PHA activated cells. In unstimulated lymphocytes, such an escape was followed by a temporary resistance to the cytotoxic effect of a further dose of HL A antibodies plus complement. In PHA activated lymphocytes, the rate of escape was higher than in unstimulated cells, and a normal sensitivity to a further dose of HL A antibodies plus complement was preserved in the whole range of time intervals explored. These findings are discussed with reference to the metabolic activation of stimulated lymphocytes as a possible factor in the process of 'shedding and regeneration' of HL A antigens.

Original languageEnglish
Pages (from-to)573-577
Number of pages5
JournalBollettino dell'Istituto Sieroterapico Milanese
Volume53
Issue number4
Publication statusPublished - 1974

ASJC Scopus subject areas

  • Immunology

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