Rational and design of EuroCRT: an international observational study on multi-modality imaging and cardiac resynchronization therapy

E Donal, V Delgado, J Magne, C Bucciarelli-Ducci, C Leclercq, B Cosyns, M Sitges, T Edvardsen, E Sade, I Stankovic, E Agricola, M Galderisi, P Lancellotti, A Hernandez, S Plein, D Muraru, E Schwammenthal, G Hindricks, BA Popescu, G Habib

Research output: Contribution to journalArticle

Abstract

Aims: Assessment of left ventricular (LV) volumes and ejection fraction (LVEF) with cardiac imaging is important in the selection of patients for cardiac resynchronization therapy (CRT). Several observational studies have explored the role of imaging-derived LV dyssynchrony parameters to predict the response to CRT, but have yielded inconsistent results, precluding the inclusion of imaging-derived LV dyssynchrony parameters in current guidelines for selection of patients for CRT. Methods: The EuroCRT is a large European multicentre prospective observational study led by the European Association of Cardiovascular Imaging. We aim to explore if combing the value of cardiac magnetic resonance (CMR) and echocardiography could be beneficial for selecting heart failure patients for CRT in terms of improvement in long-term survival, clinical symptoms, LV function, and volumes. Speckle tracking echocardiography will be used to assess LV dyssynchrony and wasted cardiac work whereas myocardial scar will be assessed with late gadolinium contrast enhanced CMR. All data will be measured in core laboratories. The study will be conducted in European centres with known expertise in both CRT and multimodality cardiac imaging.
Original languageEnglish
Pages (from-to)1120-1127
Number of pages8
JournalEuropean Heart Journal Cardiovascular Imaging
Volume18
Issue number10
DOIs
Publication statusPublished - 2017

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Cardiac Resynchronization Therapy
Observational Studies
Patient Selection
Echocardiography
Magnetic Resonance Spectroscopy
Gadolinium
Left Ventricular Function
Stroke Volume
Cicatrix
Heart Failure
Prospective Studies
Guidelines
Survival

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Rational and design of EuroCRT: an international observational study on multi-modality imaging and cardiac resynchronization therapy. / Donal, E; Delgado, V; Magne, J; Bucciarelli-Ducci, C; Leclercq, C; Cosyns, B; Sitges, M; Edvardsen, T; Sade, E; Stankovic, I; Agricola, E; Galderisi, M; Lancellotti, P; Hernandez, A; Plein, S; Muraru, D; Schwammenthal, E; Hindricks, G; Popescu, BA; Habib, G.

In: European Heart Journal Cardiovascular Imaging, Vol. 18, No. 10, 2017, p. 1120-1127.

Research output: Contribution to journalArticle

Donal, E, Delgado, V, Magne, J, Bucciarelli-Ducci, C, Leclercq, C, Cosyns, B, Sitges, M, Edvardsen, T, Sade, E, Stankovic, I, Agricola, E, Galderisi, M, Lancellotti, P, Hernandez, A, Plein, S, Muraru, D, Schwammenthal, E, Hindricks, G, Popescu, BA & Habib, G 2017, 'Rational and design of EuroCRT: an international observational study on multi-modality imaging and cardiac resynchronization therapy', European Heart Journal Cardiovascular Imaging, vol. 18, no. 10, pp. 1120-1127. https://doi.org/10.1093/ehjci/jex021
Donal, E ; Delgado, V ; Magne, J ; Bucciarelli-Ducci, C ; Leclercq, C ; Cosyns, B ; Sitges, M ; Edvardsen, T ; Sade, E ; Stankovic, I ; Agricola, E ; Galderisi, M ; Lancellotti, P ; Hernandez, A ; Plein, S ; Muraru, D ; Schwammenthal, E ; Hindricks, G ; Popescu, BA ; Habib, G. / Rational and design of EuroCRT: an international observational study on multi-modality imaging and cardiac resynchronization therapy. In: European Heart Journal Cardiovascular Imaging. 2017 ; Vol. 18, No. 10. pp. 1120-1127.
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T1 - Rational and design of EuroCRT: an international observational study on multi-modality imaging and cardiac resynchronization therapy

AU - Donal, E

AU - Delgado, V

AU - Magne, J

AU - Bucciarelli-Ducci, C

AU - Leclercq, C

AU - Cosyns, B

AU - Sitges, M

AU - Edvardsen, T

AU - Sade, E

AU - Stankovic, I

AU - Agricola, E

AU - Galderisi, M

AU - Lancellotti, P

AU - Hernandez, A

AU - Plein, S

AU - Muraru, D

AU - Schwammenthal, E

AU - Hindricks, G

AU - Popescu, BA

AU - Habib, G

PY - 2017

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N2 - Aims: Assessment of left ventricular (LV) volumes and ejection fraction (LVEF) with cardiac imaging is important in the selection of patients for cardiac resynchronization therapy (CRT). Several observational studies have explored the role of imaging-derived LV dyssynchrony parameters to predict the response to CRT, but have yielded inconsistent results, precluding the inclusion of imaging-derived LV dyssynchrony parameters in current guidelines for selection of patients for CRT. Methods: The EuroCRT is a large European multicentre prospective observational study led by the European Association of Cardiovascular Imaging. We aim to explore if combing the value of cardiac magnetic resonance (CMR) and echocardiography could be beneficial for selecting heart failure patients for CRT in terms of improvement in long-term survival, clinical symptoms, LV function, and volumes. Speckle tracking echocardiography will be used to assess LV dyssynchrony and wasted cardiac work whereas myocardial scar will be assessed with late gadolinium contrast enhanced CMR. All data will be measured in core laboratories. The study will be conducted in European centres with known expertise in both CRT and multimodality cardiac imaging.

AB - Aims: Assessment of left ventricular (LV) volumes and ejection fraction (LVEF) with cardiac imaging is important in the selection of patients for cardiac resynchronization therapy (CRT). Several observational studies have explored the role of imaging-derived LV dyssynchrony parameters to predict the response to CRT, but have yielded inconsistent results, precluding the inclusion of imaging-derived LV dyssynchrony parameters in current guidelines for selection of patients for CRT. Methods: The EuroCRT is a large European multicentre prospective observational study led by the European Association of Cardiovascular Imaging. We aim to explore if combing the value of cardiac magnetic resonance (CMR) and echocardiography could be beneficial for selecting heart failure patients for CRT in terms of improvement in long-term survival, clinical symptoms, LV function, and volumes. Speckle tracking echocardiography will be used to assess LV dyssynchrony and wasted cardiac work whereas myocardial scar will be assessed with late gadolinium contrast enhanced CMR. All data will be measured in core laboratories. The study will be conducted in European centres with known expertise in both CRT and multimodality cardiac imaging.

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