Rational base and clinical results of immunonutrition.

O. Gentilini, M. Braga, L. Gianotti

Research output: Contribution to journalArticlepeer-review


The use of enteral formulas supplemented with immunonutrients has been demonstrated to modulate gut function, inflammatory and immune response after trauma in both experimental and clinical settings. Most studies have focused on glutamine, arginine, w-3 fatty acids and nucleotides. Glutamine is an important source of nitrogen and calories and might be particularly useful in depleted patients or in patients affected by small bowel syndrome. Its use in the critical patient remains controversial. Data collected in two different recent metaanalysis consistently confirmed that enteral formulas enriched with, arginine, w-3 fatty acids and nucleotides reduced infectious complications and hospital stay after planned surgery, and decreased infectious complications, hospital stay and ventilator days in the critically ill. Mortality seems not to be affected by enteral administration of immunonutrients.

Original languageEnglish
Pages (from-to)362-366
Number of pages5
JournalMinerva Anestesiologica
Issue number5
Publication statusPublished - May 2000

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine


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