Rational development of antigen-specific therapies for type 1 diabetes

Georgia Fousteri, Damien Bresson, Matthias Von Herrath

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Administration of autoantigens, especially via the mucosal route, can induce tolerance under certain circumstances. In autoimmune diabetes, mucosal vaccination with autoantigens was frequently effective in restoring tolerance in mice but has not yet succeeded in humans. Furthermore, in some instances, autoimmunity can be precipitated upon autoantigen administration. We will here briefly discuss the underlying reasons and delineate which efforts should be made in the future to rationally translate antigen-specific immunotherapy, for example, by establishing better assays to reduce the risk for possible adverse events in humans.

Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
Pages313-319
Number of pages7
Volume601
DOIs
Publication statusPublished - 2007

Publication series

NameAdvances in Experimental Medicine and Biology
Volume601
ISSN (Print)00652598

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Fousteri, G., Bresson, D., & Von Herrath, M. (2007). Rational development of antigen-specific therapies for type 1 diabetes. In Advances in Experimental Medicine and Biology (Vol. 601, pp. 313-319). (Advances in Experimental Medicine and Biology; Vol. 601). https://doi.org/10.1007/978-0-387-72005-0_34