Rationale and approaches to the prevention of smoking-related diseases: Overview of recent studies on chemoprevention of smoking-induced tumors in rodent models

Silvio De Flora, Alberto Izzotti, Francesco Dagostini, Sebastiano La Maestra, Rosanna T. Micale, Chiara Ceccaroli, Vernon E. Steele, Roumen Balansky

Research output: Contribution to journalArticle

Abstract

Tobacco smoke plays a dominant role in the epidemiology of lung cancer, cancer at other sites, and a variety of other chronic diseases. It is the leading cause of death in developed countries, and the global burden of cancer is escalating in less developed regions. For a rational implementation of strategies exploitable for the prevention smoking-related diseases, it is crucial to elucidate both the mechanisms of action of cigarette smoke and the protective mechanisms of the host organism. The imperative primary prevention goal is to avoid any type of exposure to smoke. Epidemiological studies have shown that a decrease in the consumption of cigarettes can be successful in attenuating the epidemic of lung cancer in several countries. Chemoprevention by means of dietary and/or pharmacological agents provides a complementary strategy aimed at decreasing the risk of developing smoking-associated diseases in addicted current smokers, who are unable to quit smoking, and especially in involuntary smokers and ex-smokers. The availability of new animal models that are suitable to detect the carcinogenicity of cigarette smoke and to assess the underlying molecular mechanisms provides new tools for evaluating both safety and efficacy of putative chemopreventive agents. © 2014

Original languageEnglish
Pages (from-to)105-120
Number of pages16
JournalJournal of Environmental Science and Health - Part C Environmental Carcinogenesis and Ecotoxicology Reviews
Volume32
Issue number2
DOIs
Publication statusPublished - Apr 3 2014

Fingerprint

Chemoprevention
Smoke
Rodentia
Smoking
Tobacco Products
Lung Neoplasms
Neoplasms
Primary Prevention
Developed Countries
Tobacco
Epidemiologic Studies
Cause of Death
Epidemiology
Chronic Disease
Animal Models
Pharmacology
Safety

Keywords

  • chemoprevention
  • mechanisms
  • molecular endpoints
  • prevention
  • Tobacco smoke

ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis
  • Cancer Research
  • Medicine(all)

Cite this

Rationale and approaches to the prevention of smoking-related diseases : Overview of recent studies on chemoprevention of smoking-induced tumors in rodent models. / De Flora, Silvio; Izzotti, Alberto; Dagostini, Francesco; La Maestra, Sebastiano; Micale, Rosanna T.; Ceccaroli, Chiara; Steele, Vernon E.; Balansky, Roumen.

In: Journal of Environmental Science and Health - Part C Environmental Carcinogenesis and Ecotoxicology Reviews, Vol. 32, No. 2, 03.04.2014, p. 105-120.

Research output: Contribution to journalArticle

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