Razionale e prospettive della determinazione delle catene leggere libere del siero nelle patologie infiammatorie croniche

Translated title of the contribution: Rationale and prospects of serum immunoglobulin free light chain (FLC) determination in chronic inflammatory disease

Umberto Basile, Michele Mussap

Research output: Contribution to journalArticle

Abstract

The development of serum assays for free FLC κ and λ has opened the door to new applications increasing their clinical importance beyond monoclonal gammopathies and plasma cell dyscrasias. In particular, the availability of these tests may open new prospects for diagnosing and managing various diseases characterized by chronic inflammation, namely autoimmune disease, allergic disease, viral infections, inflammatory disorders of the central nervous system and others. For most of these diseases, serum polyclonal FLC concentrations correlate with disease activity, being a potential useful index for adjusting therapeutic regimens. The aim of this review is to summarize current available data from the literature and to analyze the possible role of FLC in improving the clinical management of patients with chronic inflammatory disorders.

Translated title of the contributionRationale and prospects of serum immunoglobulin free light chain (FLC) determination in chronic inflammatory disease
Original languageItalian
Pages (from-to)357-364
Number of pages8
JournalBiochimica Clinica
Volume37
Issue number5
Publication statusPublished - Oct 2013

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical
  • Medical Laboratory Technology

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