The development of serum assays for free FLC κ and λ has opened the door to new applications increasing their clinical importance beyond monoclonal gammopathies and plasma cell dyscrasias. In particular, the availability of these tests may open new prospects for diagnosing and managing various diseases characterized by chronic inflammation, namely autoimmune disease, allergic disease, viral infections, inflammatory disorders of the central nervous system and others. For most of these diseases, serum polyclonal FLC concentrations correlate with disease activity, being a potential useful index for adjusting therapeutic regimens. The aim of this review is to summarize current available data from the literature and to analyze the possible role of FLC in improving the clinical management of patients with chronic inflammatory disorders.
|Translated title of the contribution||Rationale and prospects of serum immunoglobulin free light chain (FLC) determination in chronic inflammatory disease|
|Number of pages||8|
|Publication status||Published - Oct 2013|
ASJC Scopus subject areas
- Clinical Biochemistry
- Biochemistry, medical
- Medical Laboratory Technology