Rationale for a preliminary operational definition of physical frailty and sarcopenia in the SPRINTT trial

Matteo Cesari, Francesco Landi, Riccardo Calvani, Antonio Cherubini, Mauro Di Bari, Patrick Kortebein, Susanna Del Signore, Regis Le Lain, Bruno Vellas, Marco Pahor, Ronenn Roubenoff, Roberto Bernabei, Emanuele Marzetti, For the SPRINTT Consortium

Research output: Contribution to journalArticlepeer-review

Abstract

In the present article, the rationale that guided the operationalization of the theoretical concept of physical frailty and sarcopenia (PF&S), the condition of interest for the “Sarcopenia and Physical Frailty in Older People: Multicomponent Treatment Strategies” (SPRINTT) trial, is presented. In particular, the decisions lead to the choice of the adopted instruments, and the reasons for setting the relevant thresholds are explained. In SPRINTT, the concept of physical frailty is translated with a Short Physical Performance Battery score of ≥3 and ≤9. Concurrently, sarcopenia is defined according to the recent definitions of low muscle mass proposed by the Foundation for the National Institutes of Health—Sarcopenia Project. Given the preventive purpose of SPRINTT, older persons with mobility disability (operationalized as incapacity to complete a 400-m walk test within 15 min; primary outcome of the trial) at the baseline are not included within the diagnostic spectrum of PF&S.

Original languageEnglish
Pages (from-to)81-88
Number of pages8
JournalAging clinical and experimental research
Volume29
Issue number1
DOIs
Publication statusPublished - Feb 1 2017

Keywords

  • Aging
  • Disability
  • Physical function
  • Prevention
  • Skeletal muscle

ASJC Scopus subject areas

  • Ageing
  • Geriatrics and Gerontology

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