Translated title of the contribution: Raynaud's phenomenon: Clinical and demographic findings

W. Grassi, G. Lapadula, G. Leardini, R. Scarpa, C. Cervini, V. Pedone, G. Danieli, V. Pipitone, F. P. Cantatore, R. Numo, N. Terlizzi, O. Albano, G. Campanale, A. Pirrelli, A. Nardecchia, L. Frizziero, G. Gasbarrini, R. Meliconi, S. Ferri

Research output: Contribution to journalArticlepeer-review


The aim of this multicenter survey was to evaluate clinical and demographic findings of patients with Raynaud's phenomenon (RP). Seven hundred sixty one patients with RP were enrolled in 49 Italian centers of Rheumatology and Internal Medicine. RP was primary in 268 (35.2%) patients. An associated condition was found in 493 (64.8%) patients. Major clinical diagnoses found among patients with RP included systemic sclerosis (216 cases; 28.4%), systemic lupus erythematosus (52 cases; 6.8%), rheumatoid arthritis (38 cases; 5%), hypertension (32 cases; 4.2%), Sjogren's syndrome (30 cases; 3.9%), mixed connective tissue disease (26 cases; 3.4%), undifferentiated connective tissue disease (23 cases; 3%), fibromyalgia (19 cases; 2.5%), carpal tunnel syndrome (19 cases; 2.5%), others (39 cases; 5.1%). The analysis of the questionnaires indicated that the traditional distinction of RP in 'primary' and 'secondary' forms is not satisfactory. Two hundred twenty one patients (82.5%) with primary RP showed one or more features suggestive of an underlying associated condition (i.e., sclerodactilia, acrosclerosis, livedo reticularis, xeroftalmia, xerostomia, skin ulcerations, teleangectasias). The lack of 'suspected' symptoms was observed only in 47 (17.5%) out of 268 patients with primary RP. This study suggests that the classification of RP should be revised. A narrower definition of primary and secondary RP and a third subset ('non primary-non secondary' RP) are required.

Translated title of the contributionRaynaud's phenomenon: Clinical and demographic findings
Original languageItalian
Pages (from-to)269-279
Number of pages11
Issue number4
Publication statusPublished - 1995

ASJC Scopus subject areas

  • Rheumatology


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