TY - JOUR
T1 - Re-emergence of striatal cholinergic interneurons in movement disorders
AU - Pisani, Antonio
AU - Bernardi, Giorgio
AU - Ding, Jun
AU - Surmeier, D. James
PY - 2007/10
Y1 - 2007/10
N2 - Twenty years ago, striatal cholinergic neurons were central figures in models of basal ganglia function. But since then, they have receded in importance. Recent studies are likely to lead to their re-emergence in our thinking. Cholinergic interneurons have been implicated as key players in the induction of synaptic plasticity and motor learning, as well as in motor dysfunction. In Parkinson's disease and dystonia, diminished striatal dopaminergic signalling leads to increased release of acetylcholine by interneurons, distorting network function and inducing structural changes that undoubtedly contribute to the symptoms. By contrast, in Huntington's disease and progressive supranuclear palsy, there is a fall in striatal cholinergic markers. This review gives an overview of these recent experimental and clinical studies, placing them within the context of the pathogenesis of movement disorders.
AB - Twenty years ago, striatal cholinergic neurons were central figures in models of basal ganglia function. But since then, they have receded in importance. Recent studies are likely to lead to their re-emergence in our thinking. Cholinergic interneurons have been implicated as key players in the induction of synaptic plasticity and motor learning, as well as in motor dysfunction. In Parkinson's disease and dystonia, diminished striatal dopaminergic signalling leads to increased release of acetylcholine by interneurons, distorting network function and inducing structural changes that undoubtedly contribute to the symptoms. By contrast, in Huntington's disease and progressive supranuclear palsy, there is a fall in striatal cholinergic markers. This review gives an overview of these recent experimental and clinical studies, placing them within the context of the pathogenesis of movement disorders.
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U2 - 10.1016/j.tins.2007.07.008
DO - 10.1016/j.tins.2007.07.008
M3 - Article
C2 - 17904652
AN - SCOPUS:34848818865
VL - 30
SP - 545
EP - 553
JO - Trends in Neurosciences
JF - Trends in Neurosciences
SN - 0378-5912
IS - 10
ER -