Re-irradiation With Carbon Ion Radiotherapy for Pelvic Rectal Cancer Recurrences in Patients Previously Irradiated to the Pelvis

Amelia Barcellini, Viviana Vitolo, Lorenzo Cobianchi, Andrea Peloso, Alessandro Vanoli, Alfredo Mirandola, Angelica Facoetti, Maria Rosaria Fiore, Alberto Iannalfi, Barbara Vischioni, Francesco Cuccia, Sara Ronchi, Maria Bonora, Giulia Riva, Rachele Petrucci, Emma D'Ippolito, Francesca Dal Mas, Lorenzo Preda, Francesca Valvo

Research output: Contribution to journalArticle

Abstract

BACKGROUND/AIM: Re-irradiation of locally recurrent rectal cancer poses challenges due to the proximity of critical organs, such as the bowel. This study aimed at evaluating the safety and efficacy of re-irradiation with Carbon Ion Radiotherapy (CIRT) in rectal cancer patients with local recurrence. PATIENTS AND METHODS: Between 2014 and 2018, 14 patients were treated at the National Center of Oncological Hadrontherapy (CNAO Foundation) with CIRT for locally recurrent rectal cancer. RESULTS: All patients concluded the treatment. No G≥3 acute/late reaction nor pelvic infections were observed. The 1-year and 2-year local control rates were, 78% and 52%, respectively, and relapse occurred close to the bowel in 6 patients. The 1-year and 2-year overall survival rates were 100% and 76.2% each; while the 1-year and 2-year metastasis free survival rates were 64.3% and 43%. CONCLUSION: CIRT as re-irradiation for locally recurrent rectal cancer emerges as a safe and valid treatment with an acceptable rate of morbidity of surrounding healthy tissue.

Original languageEnglish
Pages (from-to)1547-1553
Number of pages7
JournalIn vivo (Athens, Greece)
Volume34
Issue number3
DOIs
Publication statusPublished - May 1 2020

Keywords

  • carbon ion radiotherapy
  • re-irradiation
  • Rectal cancer recurrence

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology

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  • Cite this

    Barcellini, A., Vitolo, V., Cobianchi, L., Peloso, A., Vanoli, A., Mirandola, A., Facoetti, A., Fiore, M. R., Iannalfi, A., Vischioni, B., Cuccia, F., Ronchi, S., Bonora, M., Riva, G., Petrucci, R., D'Ippolito, E., Mas, F. D., Preda, L., & Valvo, F. (2020). Re-irradiation With Carbon Ion Radiotherapy for Pelvic Rectal Cancer Recurrences in Patients Previously Irradiated to the Pelvis. In vivo (Athens, Greece), 34(3), 1547-1553. https://doi.org/10.21873/invivo.11944