Reaching and writing movements: Sensitive and reliable tools to measure genetic dystonia in children

Claudia Casellato, Giovanna Zorzi, Alessandra Pedrocchi, Giancarlo Ferrigno, Nardo Nardocci

Research output: Contribution to journalArticle

Abstract

The aim of this study was to provide a quantitative assessment of pure dystonia in a group of children. Kinematic and muscular characteristics of unconstrained movements of the upper limb, reaching and writing, were investigated. During reaching, the distinguishing factors of dystonic movement were reduced velocity, loss of muscular activation focalization, and impairment of rest-movement modulation. Muscular parameters were able to linearly discriminate the different levels of severity. These results support the hypothesis that basal ganglia dysfunction is responsible for compromising the motor activity focusing. The handwriting movement revealed that the kinematic coordination was altered depending on dystonia severity scores. The 2 protocols revealed themselves feasible and sensitive for detecting even local and subclinical signs. Hence, this work provides a contribution toward a reliable assessment of pure dystonia, crucial for clinical characterization of patients and evaluation of the different treatment options.

Original languageEnglish
Pages (from-to)822-829
Number of pages8
JournalJournal of Child Neurology
Volume26
Issue number7
DOIs
Publication statusPublished - Jul 2011

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Dystonia
Biomechanical Phenomena
Handwriting
Basal Ganglia
Upper Extremity
Motor Activity
Therapeutics

Keywords

  • dystonia
  • movement protocols
  • muscular and kinematics patterns
  • reaching
  • writing

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health

Cite this

Reaching and writing movements : Sensitive and reliable tools to measure genetic dystonia in children. / Casellato, Claudia; Zorzi, Giovanna; Pedrocchi, Alessandra; Ferrigno, Giancarlo; Nardocci, Nardo.

In: Journal of Child Neurology, Vol. 26, No. 7, 07.2011, p. 822-829.

Research output: Contribution to journalArticle

Casellato, Claudia ; Zorzi, Giovanna ; Pedrocchi, Alessandra ; Ferrigno, Giancarlo ; Nardocci, Nardo. / Reaching and writing movements : Sensitive and reliable tools to measure genetic dystonia in children. In: Journal of Child Neurology. 2011 ; Vol. 26, No. 7. pp. 822-829.
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