Reaching LDL-c targets in high-risk patients requires high-efficacy cholesterol-lowering drugs in more than 50% of cases. the results of the CHECK study

Andrea Poli, Manuela Casula, Elena Tragni, Ovidio Brignoli, Alessandro Filippi, Claudio Cricelli, Alberico L. Catapano

Research output: Contribution to journalArticle

Abstract

We estimated the need to use low-efficacy statins or high-efficacy statins or drug combinations to bring high- or very-high cardiovascular risk subjects to their LDL-c target, in a sample representative of the Italian adult population and according to the principles of reimbursement of hypercholesterolemic drugs currently used in Italy. The results allow us concluding that among high or very high cardiovascular risk patients about three patients out of five should be prescribed high-efficacy statins or drug combinations. The other two prescriptions might take into account lower-efficacy statins. If we also compute the values of HDL-c in these subjects - the large majority of which stands below the optimal values as suggested by International guidelines - we bring forward the need either to select specific statins able to increase the levels of these protective lipoproteins or to consider combination therapies of statins with fibrates or nicotinic acid. Our data might conceivably be applied to other low-cardiovascular risk countries and should be taken into account when defining the proportion of drugs with different efficacy and cost in the everyday clinical practice.

Original languageEnglish
Pages (from-to)393-396
Number of pages4
JournalPharmacological Research
Volume64
Issue number4
DOIs
Publication statusPublished - Oct 2011

Keywords

  • Cardiovascular disease
  • Cardiovascular risk
  • Cholesterol
  • HDL
  • LDL
  • Statins

ASJC Scopus subject areas

  • Pharmacology

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