Reactive oxygen metabolites and prooxidant status in children with Down's syndrome

M. Carratelli, L. Porcaro, M. Ruscica, E. De Simone, A. A E Bertelli, M. M. Corsi

Research output: Contribution to journalArticlepeer-review

Abstract

Children with Down's syndrome suffer many diseases among which cardiovascular diseases, increased susceptibility to infections, leukemia, endocrine alterations, immune defects, nutritional disturbance and mental retardation have clinical relevance. It has been suggested that the pathogenesis of Down's syndrome involves reactive oxygen species arising from a mutation in gene encoding, which disproportionately elevates superoxide dismutase activity. Reactive oxygen species and total antioxidant capacity were evaluated using two new spectrophotometric methods in a selected group of 40 children with Down's syndrome and in 20 apparently healthy children used as controls. Reactive oxygen species were significantly higher (p

Original languageEnglish
Pages (from-to)79-84
Number of pages6
JournalInternational Journal of Clinical Pharmacology Research
Volume21
Issue number2
Publication statusPublished - 2001

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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