Reactive oxygen species adversely impacts bone marrow microenvironment in diabetes

Giuseppe Mangialardi, Gaia Spinetti, Carlotta Reni, Paolo Madeddu

Research output: Contribution to journalArticle

Abstract

Significance: Patients with diabetes mellitus suffer an excess of cardiovascular complications and recover worse from them as compared with their nondiabetic peers. It is well known that microangiopathy is the cause of renal damage, blindness, and heart attacks in patients with diabetes. This review highlights molecular deficits in stem cells and a supporting microenvironment, which can be traced back to oxidative stress and ultimately reduce stem cells therapeutic potential in diabetic patients. Recent Advances: New research has shown that increased oxidative stress contributes to inducing microangiopathy in bone marrow (BM), the tissue contained inside the bones and the main source of stem cells. These precious cells not only replace old blood cells but also exert an important reparative function after acute injuries and heart attacks. Critical Issues: The starvation of BM as a consequence of microangiopathy can lead to a less efficient healing in diabetic patients with ischemic complications. Furthermore, stem cells from a patient's BM are the most used in regenerative medicine trials to mend hearts damaged by heart attacks. Future Directions: A deeper understanding of redox signaling in BM stem cells will lead to new modalities for preserving local and systemic homeostasis and to more effective treatments of diabetic cardiovascular complications. Antioxid. Redox Signal. 21, 1620-1633.

Original languageEnglish
Pages (from-to)1620-1633
Number of pages14
JournalAntioxidants and Redox Signaling
Volume21
Issue number11
DOIs
Publication statusPublished - Oct 10 2014

Fingerprint

Medical problems
Stem cells
Reactive Oxygen Species
Bone
Stem Cells
Bone Marrow
Oxidative stress
Myocardial Infarction
Oxidation-Reduction
Oxidative Stress
Bone and Bones
Regenerative Medicine
Diabetes Complications
Blindness
Starvation
Bone Marrow Cells
Blood Cells
Diabetes Mellitus
Homeostasis
Blood

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology
  • Physiology
  • Clinical Biochemistry

Cite this

Reactive oxygen species adversely impacts bone marrow microenvironment in diabetes. / Mangialardi, Giuseppe; Spinetti, Gaia; Reni, Carlotta; Madeddu, Paolo.

In: Antioxidants and Redox Signaling, Vol. 21, No. 11, 10.10.2014, p. 1620-1633.

Research output: Contribution to journalArticle

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