Reactive oxygen species: Biological stimuli of neuroblastoma cell response

Barbara Marengo, Lizzia Raffaghello, Vito Pistoia, Damiano Cottalasso, Maria Adelaide Pronzato, Umberto Maria Marinari, Cinzia Domenicotti

Research output: Contribution to journalArticlepeer-review


Reactive oxygen species play a critical role in differentiation, proliferation and apoptosis acting as 'second messengers' able to regulate sulphydryl groups in signaling molecules as protein kinase C, a family of isoenzymes involved in many cellular responses and implicated in cell transformation. Neuroblastoma is characterised by the production of oxygen intermediates and l-buthionine-S,R-sulfoximine, a glutathione-depleting agent that has been tested in the clinics, exploits this biological peculiarity to induce cell death. The latter process is mediated by the oxidative activation of PKC delta which might be involved also in the production of reactive oxygen species, thus amplifying the apoptotic cascade.

Original languageEnglish
Pages (from-to)111-116
Number of pages6
JournalCancer Letters
Issue number1-2
Publication statusPublished - Oct 18 2005


  • Apoptosis
  • MYCN amplification
  • Neuroblastoma
  • Protein kinase C
  • Reactive oxygen species

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology


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