Reactivity of cortical alpha rhythms to eye opening in mild cognitive impairment and Alzheimer's disease: An EEG study

Research output: Contribution to journalArticle

Abstract

Cortical sources of resting eyes-closed alpha rhythms are typically abnormal in mild cognitive impairment (MCI) and Alzheimer's disease (AD) subjects. Here we tested the hypothesis of a progressive impairment of cortical alpha reactivity to eye-opening across amnesic MCI and mild AD subjects, reflecting another aspect of the impairment of cortical neural synchronization. Resting electroencephalography (EEG) data were recorded in 36 normal elderly subjects (Nold), 91 amnesic MCI, and 31 mild AD subjects during eyes-closed and -open conditions. EEG sources were estimated by LORETA software. In the eye-closed condition, posterior alpha 1 (8-10.5 Hz) sources were lower in MCI and AD than Nold subjects. The opposite was true for occipital delta sources (2-4 Hz). Reactivity to the eyes-open condition showed posterior alpha 1 and alpha 2 (10.5-13 Hz) sources was high in the Nold, intermediate in the MCI, and low in the AD subjects. Furthermore, occipital alpha 1 reactivity across MCI and AD subjects was correlated to the cognitive impairment as revealed by Mini-Mental State Examination score. In conclusion, at least at group level, the continuum across amnesic MCI and mild AD status is related to an impaired reactivity of cortical neuronal synchronization to eyes opening at alpha rhythms.

Original languageEnglish
Pages (from-to)1047-1064
Number of pages18
JournalJournal of Alzheimer's Disease
Volume22
Issue number4
DOIs
Publication statusPublished - 2010

Keywords

  • Alzheimer's disease
  • amnesic mild cognitive impairment
  • and alpha rhythms
  • delta
  • electroencephalography
  • eyes-closed resting state
  • eyes-open resting state
  • low resolution brain electromagnetic tomography (LORETA)
  • theta

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Clinical Psychology

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