Reactogenicity and immunogenicity of adult versus paediatric diphtheria and tetanus booster dose at 6 years of age

M. L. Ciofi Degli Atti, S. Salmaso, B. Cotter, G. Gallo, G. Alfarone, A. Pinto, A. Bella, C. Von Hunolstein

Research output: Contribution to journalArticle


We evaluated the reactogenicity and immunogenicity of a booster dose of diphtheria-tetanus vaccine administered at the age of school-entry, comparing a low-dose vaccine (dT) to the standard paediatric dose (DT). Participants were randomly assigned to receive one of the two vaccines; the study was evaluator-blinded. The frequency of side-reactions was similar when comparing the two groups, except when considering local redness and swelling, which were significantly more frequent among the DT group. The post-booster geometric mean titre of diphtheria antibodies in the DT group was twice as high as that in the dT group (14.1IU/ml versus 7.7IU/ml; P <0.001). The higher antibody response and the comparable reactogenicity indicate that DT should be used as booster at school-entry, particularly if additional booster doses during adolescence or adulthood are not administered.

Original languageEnglish
Pages (from-to)74-79
Number of pages6
Issue number1-2
Publication statusPublished - Oct 12 2001



  • Booster
  • Diphtheria
  • Vaccination

ASJC Scopus subject areas

  • Immunology
  • Microbiology
  • Virology
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • veterinary(all)

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