Reading, writing, and reserve: Literacy activities are linked to hippocampal volume and memory in multiple sclerosis

James F. Sumowski; Maria A. Rocca; Victoria M. Leavitt; Gianna Riccitelli; Alessandro Meani; Giancarlo Comi; Massimo Filippi

doi:10.1177/1352458516630822

Reading, writing, and reserve: Literacy activities are linked to hippocampal volume and memory in multiple sclerosis

James F. Sumowski, Maria A. Rocca, Victoria M. Leavitt, Gianna Riccitelli, Alessandro Meani, Giancarlo Comi, Massimo Filippi

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Engagement in cognitive leisure activities during early adulthood has been linked to preserved memory and larger hippocampal volume in persons with multiple sclerosis (MS). Objective: To investigate which specific types of cognitive leisure activities contribute to hippocampal volume and memory. Methods: We investigated links between three types of cognitive activities (Reading-Writing, Art-Music, Games-Hobbies) and (a) hippocampal volume within independent samples of Italian (n=187) and American (n=55) MS patients and (b) memory in subsamples of Italian (n=97) and American (n=53) patients. Results: Reading-Writing was the only predictor of hippocampal volume (rp=.204, p=.002), and the best predictor of memory (rp=.288, p=.001). Conclusions: Findings inform the development of targeted evidence-based enrichment programs aiming to bolster reserve against memory decline.

Original language	English
Pages (from-to)	1621-1625
Number of pages	5
Journal	Multiple Sclerosis
Volume	22
Issue number	12
DOIs	https://doi.org/10.1177/1352458516630822
Publication status	Published - Oct 1 2016

Keywords

cognitive reserve
enriched environments
hippocampal volume
Multiple sclerosis
neurogenesis

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1177/1352458516630822

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title = "Reading, writing, and reserve: Literacy activities are linked to hippocampal volume and memory in multiple sclerosis",

abstract = "Background: Engagement in cognitive leisure activities during early adulthood has been linked to preserved memory and larger hippocampal volume in persons with multiple sclerosis (MS). Objective: To investigate which specific types of cognitive leisure activities contribute to hippocampal volume and memory. Methods: We investigated links between three types of cognitive activities (Reading-Writing, Art-Music, Games-Hobbies) and (a) hippocampal volume within independent samples of Italian (n=187) and American (n=55) MS patients and (b) memory in subsamples of Italian (n=97) and American (n=53) patients. Results: Reading-Writing was the only predictor of hippocampal volume (rp=.204, p=.002), and the best predictor of memory (rp=.288, p=.001). Conclusions: Findings inform the development of targeted evidence-based enrichment programs aiming to bolster reserve against memory decline.",

keywords = "cognitive reserve, enriched environments, hippocampal volume, Multiple sclerosis, neurogenesis",

author = "Sumowski, {James F.} and Rocca, {Maria A.} and Leavitt, {Victoria M.} and Gianna Riccitelli and Alessandro Meani and Giancarlo Comi and Massimo Filippi",

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T1 - Reading, writing, and reserve

T2 - Literacy activities are linked to hippocampal volume and memory in multiple sclerosis

AU - Sumowski, James F.

AU - Rocca, Maria A.

AU - Leavitt, Victoria M.

AU - Riccitelli, Gianna

AU - Meani, Alessandro

AU - Comi, Giancarlo

AU - Filippi, Massimo

PY - 2016/10/1

Y1 - 2016/10/1

N2 - Background: Engagement in cognitive leisure activities during early adulthood has been linked to preserved memory and larger hippocampal volume in persons with multiple sclerosis (MS). Objective: To investigate which specific types of cognitive leisure activities contribute to hippocampal volume and memory. Methods: We investigated links between three types of cognitive activities (Reading-Writing, Art-Music, Games-Hobbies) and (a) hippocampal volume within independent samples of Italian (n=187) and American (n=55) MS patients and (b) memory in subsamples of Italian (n=97) and American (n=53) patients. Results: Reading-Writing was the only predictor of hippocampal volume (rp=.204, p=.002), and the best predictor of memory (rp=.288, p=.001). Conclusions: Findings inform the development of targeted evidence-based enrichment programs aiming to bolster reserve against memory decline.

AB - Background: Engagement in cognitive leisure activities during early adulthood has been linked to preserved memory and larger hippocampal volume in persons with multiple sclerosis (MS). Objective: To investigate which specific types of cognitive leisure activities contribute to hippocampal volume and memory. Methods: We investigated links between three types of cognitive activities (Reading-Writing, Art-Music, Games-Hobbies) and (a) hippocampal volume within independent samples of Italian (n=187) and American (n=55) MS patients and (b) memory in subsamples of Italian (n=97) and American (n=53) patients. Results: Reading-Writing was the only predictor of hippocampal volume (rp=.204, p=.002), and the best predictor of memory (rp=.288, p=.001). Conclusions: Findings inform the development of targeted evidence-based enrichment programs aiming to bolster reserve against memory decline.

KW - cognitive reserve

KW - enriched environments

KW - hippocampal volume

KW - Multiple sclerosis

KW - neurogenesis

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Reading, writing, and reserve: Literacy activities are linked to hippocampal volume and memory in multiple sclerosis

Abstract

Keywords

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