Real life experience with frontline azacitidine in a large series of older adults with acute myeloid leukemia stratified by MRC/LRF score: results from the expanded international E-ALMA series (E-ALMA+)

José Falantes, Lisa Pleyer, Sylvain Thépot, António M. Almeida, Luca Maurillo, Violeta Martínez-Robles, Reinhard Stauder, Raphael Itzykson, Ricardo Pinto, Adriano Venditti, Joan Bargay, Sonja Burgstaller, María Pilar Martínez, Valerie Seegers, Emilia Cortesão, María Ángeles Foncillas, Claude Gardin, Pau Montesinos, Pellegrino Musto, Pierre FenauxRichard Greil, Miguel Angel Sanz, Fernando Ramos

Research output: Contribution to journalArticlepeer-review

Abstract

Azacitidine (AZA) prolonged overall survival (OS) in the AZA-AML-001 trial. However, few subjects were randomized to AZA or intensive chemotherapy (IC). The Medical Research Council (MRC) and the Leukemia Research Foundation (LRF) developed a score for older AML patients receiving IC or non-intensive regimens, whereas the E-ALMA study validated a score for survival and response in elderly patients receiving AZA in daily practice. Both identified three groups with different risk estimates. This analysis evaluates the efficacy of frontline AZA in older AML patients (N = 710) unfit for IC from different national registries (E-ALMA + series) stratified by the MRC/LRF risk score. Median OS of patients categorized as good, standard and poor-risk groups by the MRC/LRF score was 13.4 (95% CI, 10.8–16), 12.4 (95% CI, 9.9–14.8), and 8.1 months (95% CI, 7–9.1), respectively (p = .0001). In conclusion, this is the largest retrospective cohort of older AML patients treated with AZA.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalLeukemia and Lymphoma
DOIs
Publication statusAccepted/In press - Aug 25 2017

Keywords

  • Acute myeloid leukemia
  • azacitidine
  • E-ALMA+
  • elderly
  • MRC/LRF risk score

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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