Real-Life Management of Children and Adolescents with Chronic Myeloid Leukemia: The Italian Experience

Fiorina Giona, Michelina Santopietro, Giuseppe Menna, Maria Caterina Putti, Concetta Micalizzi, Nicola Santoro, Ottavio Ziino, Rosamaria Mura, Saverio Ladogana, Grazia Iaria, Antonella Sau, Roberta Burnelli, Nadia Vacca, Sayla Bernasconi, Caterina Consarino, Fara Petruzziello, Maria Luisa Moleti, Andrea Biondi, Franco Locatelli, Robin Foà

Research output: Contribution to journalArticlepeer-review


BACKGROUND: To date, no data on the adherence to specific guidelines for children with chronic myeloid leukemia (CML) in chronic phase (CP) have been reported.

METHODS: Since 2001, guidelines for treatment with imatinib mesylate (IM) and monitoring in patients younger than 18 years with CP-CML have been shared with 9 pediatric referral centers (P centers) and 4 reference centers for adults and children/adolescents (AP centers) in Italy. In this study, the adherence to these guidelines was analyzed.

RESULTS: Thirty-four patients with a median age of 11.4 years and 23 patients with a median age of 11.0 years were managed at 9 P and at 4 AP centers, respectively. Evaluations of bone marrow (BM) and/or peripheral blood (PB) were available for more than 90% of evaluable patients. Cytogenetics and molecular monitoring of PB were more consistently performed in AP centers, whereas molecular analysis of BM was carried out more frequently in P centers. Before 2009, some patients who responded to IM underwent a transplantation, contrary to the guidelines' recommendations.

CONCLUSIONS: Our experience shows that having specific guidelines is an important tool for an optimal management of childhood CP-CML, together with exchange of knowledge and proactive discussions within the network.

Original languageEnglish
Pages (from-to)105-111
Number of pages7
JournalActa Haematologica
Issue number2
Publication statusPublished - 2018


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