Real-time contrast-enhanced specific ultrasound in staging and follow-up of splenic lymphomas

Salvatore Tafuto, Orlando Catalano, Gianvincenzo Barba, Fabio Sandomenico, Roberto Lobianco, Anna Tortoriello, Roberta Formato, Pasquale Comella, Alfredo Siani, Marilisa Di Meo, Rosario Vincenzo Iaffaioli, Stefano Quattrin

Research output: Contribution to journalArticlepeer-review


From January 2003 to April 2005 we studied 25 lymphoma patients (10 with HD, 4 with low-grade NHL, 6 with high-grade NHL and 5 with chronic lymphatic leukaemia; 14 men, 11 women, age range 28-79 years). After a baseline US study we rapidly injected 4.8 mL of the second-generation microbubble contrast agent SonoVue (Bracco, Italy). Contrast enhanced studies were carried out with the contrast-specific software named Contrast Tuned Imaging (Esaote, Italy) using a continous, harmonic acquisition and a low acoustic pressure. The CS-US findings were correlated with results of standard tools, including CT, MRI, US follow up. CS-US revealed correctly 47 out of the 52 lesions identified by CT scan, in the absence of false positive findings (sensitivity=90%; Specificity= 100%, in comparison to CT scan). Complete concordance in evaluating the lesion extension of the CS-US in respect to CT was 88%, while underestimate occurred in 9% and overestimate in 3% of cases. On the contrary, basic sonography defined correctly the dimensional alteration in 52% of the cases, underestimated in 35% and overestimated in 13%, thus showing significantly lower accuracy (chi-square = 30.0, p

Original languageEnglish
Pages (from-to)2224-2229
Number of pages6
JournalFrontiers in Bioscience
Issue numberSUPPL. 1
Publication statusPublished - 2006


  • Cancer
  • Contrast-Enhanced Specific Ultrasound
  • Lymph node
  • Lymphomas
  • Staging
  • Tumor

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology


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