TY - JOUR
T1 - Real-time contrast-enhanced specific ultrasound in staging and follow-up of splenic lymphomas
AU - Tafuto, Salvatore
AU - Catalano, Orlando
AU - Barba, Gianvincenzo
AU - Sandomenico, Fabio
AU - Lobianco, Roberto
AU - Tortoriello, Anna
AU - Formato, Roberta
AU - Comella, Pasquale
AU - Siani, Alfredo
AU - Di Meo, Marilisa
AU - Iaffaioli, Rosario Vincenzo
AU - Quattrin, Stefano
PY - 2006
Y1 - 2006
N2 - From January 2003 to April 2005 we studied 25 lymphoma patients (10 with HD, 4 with low-grade NHL, 6 with high-grade NHL and 5 with chronic lymphatic leukaemia; 14 men, 11 women, age range 28-79 years). After a baseline US study we rapidly injected 4.8 mL of the second-generation microbubble contrast agent SonoVue (Bracco, Italy). Contrast enhanced studies were carried out with the contrast-specific software named Contrast Tuned Imaging (Esaote, Italy) using a continous, harmonic acquisition and a low acoustic pressure. The CS-US findings were correlated with results of standard tools, including CT, MRI, US follow up. CS-US revealed correctly 47 out of the 52 lesions identified by CT scan, in the absence of false positive findings (sensitivity=90%; Specificity= 100%, in comparison to CT scan). Complete concordance in evaluating the lesion extension of the CS-US in respect to CT was 88%, while underestimate occurred in 9% and overestimate in 3% of cases. On the contrary, basic sonography defined correctly the dimensional alteration in 52% of the cases, underestimated in 35% and overestimated in 13%, thus showing significantly lower accuracy (chi-square = 30.0, p
AB - From January 2003 to April 2005 we studied 25 lymphoma patients (10 with HD, 4 with low-grade NHL, 6 with high-grade NHL and 5 with chronic lymphatic leukaemia; 14 men, 11 women, age range 28-79 years). After a baseline US study we rapidly injected 4.8 mL of the second-generation microbubble contrast agent SonoVue (Bracco, Italy). Contrast enhanced studies were carried out with the contrast-specific software named Contrast Tuned Imaging (Esaote, Italy) using a continous, harmonic acquisition and a low acoustic pressure. The CS-US findings were correlated with results of standard tools, including CT, MRI, US follow up. CS-US revealed correctly 47 out of the 52 lesions identified by CT scan, in the absence of false positive findings (sensitivity=90%; Specificity= 100%, in comparison to CT scan). Complete concordance in evaluating the lesion extension of the CS-US in respect to CT was 88%, while underestimate occurred in 9% and overestimate in 3% of cases. On the contrary, basic sonography defined correctly the dimensional alteration in 52% of the cases, underestimated in 35% and overestimated in 13%, thus showing significantly lower accuracy (chi-square = 30.0, p
KW - Cancer
KW - Contrast-Enhanced Specific Ultrasound
KW - Lymph node
KW - Lymphomas
KW - Staging
KW - Tumor
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U2 - 10.2741/1965
DO - 10.2741/1965
M3 - Article
C2 - 16720309
AN - SCOPUS:33744776922
VL - 11
SP - 2224
EP - 2229
JO - Frontiers in Bioscience - Landmark
JF - Frontiers in Bioscience - Landmark
SN - 1093-9946
IS - SUPPL. 1
ER -