Real-time measurement of particulate matter deposition in the lung

G. Invernizzi, R. Boffi, A. A. Ruprecht, P. J. Barnes, S. A. Kharitonov, Paolo Paredi

Research output: Contribution to journalArticlepeer-review


Air pollution and cigarette smoke are recognized health risks. A method was developed for the measurement of the deposition fraction (DF) of polydisperse particulate matter (PM) in human airways. Ten normal volunteers [three females, age range 18-67 years, mean age (SD) 43.9 (14)] made single breath exhalations after inhalation to total lung capacity. The exhaled breath was diverted to a multichannel laser diffraction chamber where the particulate profiler measured 0.3-1.0-μm particles. DF was inversely related to expiration flow-rate, 0.69 (0.02) at 4 l min-1 and 0.5 (0.01) at 13 l min-1, respectively (p -1 and 0.59 (0.02) at 13 l min-1, respectively (P0.05). Higher breath holding times were associated with elevated DF [0.74 (0.02) at 20 s, and 0.62 (0.05) without breath holding (p

Original languageEnglish
Pages (from-to)221-232
Number of pages12
Issue number3
Publication statusPublished - May 2006


  • Exhaled breath
  • Lung inflammation
  • Particle deposition
  • Particulate matter
  • Pollution

ASJC Scopus subject areas

  • Biotechnology
  • Toxicology


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