Real-Time Three-Dimensional Echocardiography as a Novel Approach to Quantify Left Ventricular Dyssynchrony: A Comparison Study with Phase Analysis of Gated Myocardial Perfusion Single Photon Emission Computed Tomography

Nina Ajmone Marsan, Maureen M. Henneman, Ji Chen, Claudia Ypenburg, Petra Dibbets, Stefano Ghio, Gabe B. Bleeker, Marcel P. Stokkel, Ernst E. van der Wall, Luigi Tavazzi, Ernest V. Garcia, Jeroen J. Bax

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Different imaging modalities have been explored for assessment of left ventricular (LV) dyssynchrony. Gated myocardial perfusion single photon emission computed tomography (GMPS) with phase analysis is a reliable technique to quantify LV dyssynchrony and predict response to cardiac resynchronization therapy. Objective: Real-time 3-dimensional echocardiography (RT3DE) is a novel imaging technique that provides a LV systolic dyssynchrony index, based on regional volumetric changes as a function of time and calculated as the SD of time to minimum systolic volume of 16 standard myocardial segments expressed in percentage of cardiac cycle. The aim of this study was to compare LV dyssynchrony evaluated with GMPS with LV dyssynchrony assessed with RT3DE. Methods: The study population consisted of 40 patients with heart failure who underwent both GMPS and RT3DE. Results: Good correlations between LV dyssynchrony assessed with RT3DE and GMPS were demonstrated (r = 0.76 for histogram bandwidth, r = 0.80 for phase SD, P <.0001). Patients with substantial LV dyssynchrony on GMPS (defined as ≥135 degrees for histogram bandwidth and ≥43 degrees for phase SD) had significantly higher LV systolic dyssynchrony index than patients without substantial LV dyssynchrony. Conclusions: The good correlations between LV dyssynchrony assessed with GMPS and with RT3DE provide further support for the use of RT3DE for reliable assessment of LV dyssynchrony.

Original languageEnglish
Pages (from-to)801-807
Number of pages7
JournalJournal of the American Society of Echocardiography
Volume21
Issue number7
DOIs
Publication statusPublished - Jul 2008

Keywords

  • Heart failure
  • Left ventricular dyssynchrony
  • Left ventricular function
  • SPECT
  • Three-dimensional echocardiography

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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