Real-time three-dimensional echocardiography as a novel approach to assess left ventricular and left atrium reverse remodeling and to predict response to cardiac resynchronization therapy

Nina Ajmone Marsan, Gabe B. Bleeker, Claudia Ypenburg, Rutger J. Van Bommel, Stefano Ghio, Nico R. Van de Veire, Victoria Delgado, Eduard R. Holman, Ernst E. van der Wall, Martin J. Schalij, Jeroen J. Bax

Research output: Contribution to journalArticle

Abstract

Background: Real-time 3-dimensional echocardiography (RT3DE) is a novel promising technique for the assessment of left ventricular (LV) dyssynchrony. Objective: This study sought to explore the value of RT3DE to assess LV and left atrium (LA) reverse remodeling and to predict response to cardiac resynchronization therapy (CRT). Methods: A total of 57 consecutive heart failure patients scheduled for CRT were included, and RT3DE was performed before and 6 months after implantation. LV dyssynchrony was defined as the standard deviation of the time to reach the minimum systolic volume for 16 LV segments, expressed in percentage of cardiac cycle (systolic dyssynchrony index, SDI). Patients were divided into responders or nonresponders, based on a reduction ≥15% in LV end-systolic volume after CRT. Results: Six patients (10%) were excluded from further analysis because of suboptimal images. Of the remaining 51 patients, 34 (67%) were classified as responders. Baseline characteristics were similar between responders and nonresponders, except for the SDI, which was larger in responders (9.7% ± 3.6% versus 5.1% ± 1.8%, P

Original languageEnglish
Pages (from-to)1257-1264
Number of pages8
JournalHeart Rhythm
Volume5
Issue number9
DOIs
Publication statusPublished - Sep 2008

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Keywords

  • Cardiac resynchronization therapy
  • Heart failure
  • Left atrium
  • Left ventricular dyssynchrony
  • Left ventricular remodeling
  • Real-time three-dimensional echocardiography

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Marsan, N. A., Bleeker, G. B., Ypenburg, C., Van Bommel, R. J., Ghio, S., Van de Veire, N. R., Delgado, V., Holman, E. R., van der Wall, E. E., Schalij, M. J., & Bax, J. J. (2008). Real-time three-dimensional echocardiography as a novel approach to assess left ventricular and left atrium reverse remodeling and to predict response to cardiac resynchronization therapy. Heart Rhythm, 5(9), 1257-1264. https://doi.org/10.1016/j.hrthm.2008.05.021