Real-time tumour tracking in particle therapy: Technological developments and future perspectives

Marco Riboldi, Roberto Orecchia, Guido Baroni

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

A key challenge in radiation oncology is accurate delivery of the prescribed dose to tumours that move because of respiration. Tumour tracking involves real-time target localisation and correction of radiation beam geometry to compensate for motion. Uncertainties in tumour localisation are important in particle therapy (proton therapy, carbon-ion therapy) because charged particle beams are highly sensitive to geometrical and associated density and radiological variations in path length, which will affect the treatment plan. Target localisation and motion compensation methods applied in x-ray photon radiotherapy require careful performance assessment for clinical applications in particle therapy. In this Review, we summarise the efforts required for an application of real-time tumour tracking in particle therapy, by comparing and assessing competing strategies for time-resolved target localisation and related clinical outcomes in x-ray radiation oncology.

Original languageEnglish
JournalThe Lancet Oncology
Volume13
Issue number9
DOIs
Publication statusPublished - Sep 2012

Fingerprint

Radiation Oncology
Neoplasms
Heavy Ion Radiotherapy
X-Rays
Proton Therapy
Therapeutics
Photons
Uncertainty
Respiration
Radiotherapy
Radiation

ASJC Scopus subject areas

  • Oncology

Cite this

Real-time tumour tracking in particle therapy : Technological developments and future perspectives. / Riboldi, Marco; Orecchia, Roberto; Baroni, Guido.

In: The Lancet Oncology, Vol. 13, No. 9, 09.2012.

Research output: Contribution to journalArticle

@article{08a6edf5df7548c3a4374d6e07bde56f,
title = "Real-time tumour tracking in particle therapy: Technological developments and future perspectives",
abstract = "A key challenge in radiation oncology is accurate delivery of the prescribed dose to tumours that move because of respiration. Tumour tracking involves real-time target localisation and correction of radiation beam geometry to compensate for motion. Uncertainties in tumour localisation are important in particle therapy (proton therapy, carbon-ion therapy) because charged particle beams are highly sensitive to geometrical and associated density and radiological variations in path length, which will affect the treatment plan. Target localisation and motion compensation methods applied in x-ray photon radiotherapy require careful performance assessment for clinical applications in particle therapy. In this Review, we summarise the efforts required for an application of real-time tumour tracking in particle therapy, by comparing and assessing competing strategies for time-resolved target localisation and related clinical outcomes in x-ray radiation oncology.",
author = "Marco Riboldi and Roberto Orecchia and Guido Baroni",
year = "2012",
month = "9",
doi = "10.1016/S1470-2045(12)70243-7",
language = "English",
volume = "13",
journal = "The Lancet Oncology",
issn = "1470-2045",
publisher = "Lancet Publishing Group",
number = "9",

}

TY - JOUR

T1 - Real-time tumour tracking in particle therapy

T2 - Technological developments and future perspectives

AU - Riboldi, Marco

AU - Orecchia, Roberto

AU - Baroni, Guido

PY - 2012/9

Y1 - 2012/9

N2 - A key challenge in radiation oncology is accurate delivery of the prescribed dose to tumours that move because of respiration. Tumour tracking involves real-time target localisation and correction of radiation beam geometry to compensate for motion. Uncertainties in tumour localisation are important in particle therapy (proton therapy, carbon-ion therapy) because charged particle beams are highly sensitive to geometrical and associated density and radiological variations in path length, which will affect the treatment plan. Target localisation and motion compensation methods applied in x-ray photon radiotherapy require careful performance assessment for clinical applications in particle therapy. In this Review, we summarise the efforts required for an application of real-time tumour tracking in particle therapy, by comparing and assessing competing strategies for time-resolved target localisation and related clinical outcomes in x-ray radiation oncology.

AB - A key challenge in radiation oncology is accurate delivery of the prescribed dose to tumours that move because of respiration. Tumour tracking involves real-time target localisation and correction of radiation beam geometry to compensate for motion. Uncertainties in tumour localisation are important in particle therapy (proton therapy, carbon-ion therapy) because charged particle beams are highly sensitive to geometrical and associated density and radiological variations in path length, which will affect the treatment plan. Target localisation and motion compensation methods applied in x-ray photon radiotherapy require careful performance assessment for clinical applications in particle therapy. In this Review, we summarise the efforts required for an application of real-time tumour tracking in particle therapy, by comparing and assessing competing strategies for time-resolved target localisation and related clinical outcomes in x-ray radiation oncology.

UR - http://www.scopus.com/inward/record.url?scp=84865556751&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84865556751&partnerID=8YFLogxK

U2 - 10.1016/S1470-2045(12)70243-7

DO - 10.1016/S1470-2045(12)70243-7

M3 - Article

C2 - 22935238

AN - SCOPUS:84865556751

VL - 13

JO - The Lancet Oncology

JF - The Lancet Oncology

SN - 1470-2045

IS - 9

ER -