Real-world effectiveness and safety of glecaprevir/pibrentasvir in 723 patients with chronic hepatitis C

R. D'Ambrosio, L. Pasulo, M. Puoti, M. Vinci, M. Schiavini, S. Lazzaroni, A. Soria, F. Gatti, B. Menzaghi, A. Aghemo, F. Capelli, M.G. Rumi, L. Morini, A. Giorgini, M.G. Pigozzi, A. Rossini, F. Maggiolo, A. Pan, M. Memoli, O. SpinelliP. Del Poggio, V. Saladino, A. Spinetti, A. De Bona, A. Capretti, C. Uberti-Foppa, P. Bonfanti, N. Terreni, F. Menozzi, A.E. Colombo, O. Giglio, R. Centenaro, M. Borghi, C. Baiguera, V. Picciotto, S. Landonio, A. Gori, C. Magnani, F. Noventa, S. Paolucci, P. Lampertico, S. Fagiuoli

Research output: Contribution to journalArticle

Original languageEnglish
Pages (from-to)379-387
Number of pages9
JournalJournal of Hepatology
Volume70
Issue number3
DOIs
Publication statusPublished - 2019

Keywords

  • DAA
  • Effectiveness
  • Glecaprevir
  • HCV
  • Pibrentasvir
  • RAS
  • Real-life
  • Safety
  • SVR
  • bilirubin
  • glecaprevir plus pibrentasvir
  • interferon
  • virus RNA
  • adult
  • aged
  • Article
  • chronic hepatitis C
  • chronic kidney failure
  • clinical effectiveness
  • cohort analysis
  • depression
  • drug safety
  • drug tolerability
  • drug withdrawal
  • estimated glomerular filtration rate
  • fatigue
  • female
  • headache
  • Hepatitis C virus genotype 1
  • Hepatitis C virus genotype 2
  • Hepatitis C virus genotype 3
  • human
  • Human immunodeficiency virus infection
  • hypertensive crisis
  • insomnia
  • intention to treat analysis
  • jaundice
  • liver stiffness
  • longitudinal study
  • major clinical study
  • male
  • mixed infection
  • multicenter study (topic)
  • nausea
  • nonhuman
  • patient compliance
  • platelet count
  • priority journal
  • pruritus
  • relapse
  • retrospective study
  • side effect
  • sustained virologic response
  • treatment duration
  • treatment response
  • vomiting

Cite this

Real-world effectiveness and safety of glecaprevir/pibrentasvir in 723 patients with chronic hepatitis C. / D'Ambrosio, R.; Pasulo, L.; Puoti, M.; Vinci, M.; Schiavini, M.; Lazzaroni, S.; Soria, A.; Gatti, F.; Menzaghi, B.; Aghemo, A.; Capelli, F.; Rumi, M.G.; Morini, L.; Giorgini, A.; Pigozzi, M.G.; Rossini, A.; Maggiolo, F.; Pan, A.; Memoli, M.; Spinelli, O.; Del Poggio, P.; Saladino, V.; Spinetti, A.; De Bona, A.; Capretti, A.; Uberti-Foppa, C.; Bonfanti, P.; Terreni, N.; Menozzi, F.; Colombo, A.E.; Giglio, O.; Centenaro, R.; Borghi, M.; Baiguera, C.; Picciotto, V.; Landonio, S.; Gori, A.; Magnani, C.; Noventa, F.; Paolucci, S.; Lampertico, P.; Fagiuoli, S.

In: Journal of Hepatology, Vol. 70, No. 3, 2019, p. 379-387.

Research output: Contribution to journalArticle

D'Ambrosio, R, Pasulo, L, Puoti, M, Vinci, M, Schiavini, M, Lazzaroni, S, Soria, A, Gatti, F, Menzaghi, B, Aghemo, A, Capelli, F, Rumi, MG, Morini, L, Giorgini, A, Pigozzi, MG, Rossini, A, Maggiolo, F, Pan, A, Memoli, M, Spinelli, O, Del Poggio, P, Saladino, V, Spinetti, A, De Bona, A, Capretti, A, Uberti-Foppa, C, Bonfanti, P, Terreni, N, Menozzi, F, Colombo, AE, Giglio, O, Centenaro, R, Borghi, M, Baiguera, C, Picciotto, V, Landonio, S, Gori, A, Magnani, C, Noventa, F, Paolucci, S, Lampertico, P & Fagiuoli, S 2019, 'Real-world effectiveness and safety of glecaprevir/pibrentasvir in 723 patients with chronic hepatitis C', Journal of Hepatology, vol. 70, no. 3, pp. 379-387. https://doi.org/10.1016/j.jhep.2018.11.011
D'Ambrosio, R. ; Pasulo, L. ; Puoti, M. ; Vinci, M. ; Schiavini, M. ; Lazzaroni, S. ; Soria, A. ; Gatti, F. ; Menzaghi, B. ; Aghemo, A. ; Capelli, F. ; Rumi, M.G. ; Morini, L. ; Giorgini, A. ; Pigozzi, M.G. ; Rossini, A. ; Maggiolo, F. ; Pan, A. ; Memoli, M. ; Spinelli, O. ; Del Poggio, P. ; Saladino, V. ; Spinetti, A. ; De Bona, A. ; Capretti, A. ; Uberti-Foppa, C. ; Bonfanti, P. ; Terreni, N. ; Menozzi, F. ; Colombo, A.E. ; Giglio, O. ; Centenaro, R. ; Borghi, M. ; Baiguera, C. ; Picciotto, V. ; Landonio, S. ; Gori, A. ; Magnani, C. ; Noventa, F. ; Paolucci, S. ; Lampertico, P. ; Fagiuoli, S. / Real-world effectiveness and safety of glecaprevir/pibrentasvir in 723 patients with chronic hepatitis C. In: Journal of Hepatology. 2019 ; Vol. 70, No. 3. pp. 379-387.
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title = "Real-world effectiveness and safety of glecaprevir/pibrentasvir in 723 patients with chronic hepatitis C",
keywords = "DAA, Effectiveness, Glecaprevir, HCV, Pibrentasvir, RAS, Real-life, Safety, SVR, bilirubin, glecaprevir plus pibrentasvir, interferon, virus RNA, adult, aged, Article, chronic hepatitis C, chronic kidney failure, clinical effectiveness, cohort analysis, depression, drug safety, drug tolerability, drug withdrawal, estimated glomerular filtration rate, fatigue, female, headache, Hepatitis C virus genotype 1, Hepatitis C virus genotype 2, Hepatitis C virus genotype 3, human, Human immunodeficiency virus infection, hypertensive crisis, insomnia, intention to treat analysis, jaundice, liver stiffness, longitudinal study, major clinical study, male, mixed infection, multicenter study (topic), nausea, nonhuman, patient compliance, platelet count, priority journal, pruritus, relapse, retrospective study, side effect, sustained virologic response, treatment duration, treatment response, vomiting",
author = "R. D'Ambrosio and L. Pasulo and M. Puoti and M. Vinci and M. Schiavini and S. Lazzaroni and A. Soria and F. Gatti and B. Menzaghi and A. Aghemo and F. Capelli and M.G. Rumi and L. Morini and A. Giorgini and M.G. Pigozzi and A. Rossini and F. Maggiolo and A. Pan and M. Memoli and O. Spinelli and {Del Poggio}, P. and V. Saladino and A. Spinetti and {De Bona}, A. and A. Capretti and C. Uberti-Foppa and P. Bonfanti and N. Terreni and F. Menozzi and A.E. Colombo and O. Giglio and R. Centenaro and M. Borghi and C. Baiguera and V. Picciotto and S. Landonio and A. Gori and C. Magnani and F. Noventa and S. Paolucci and P. Lampertico and S. Fagiuoli",
note = "Export Date: 1 July 2019 CODEN: JOHEE Correspondence Address: D'Ambrosio, R.; CRC “AM e A Migliavacca” Center for Liver Diseases, Division of Gastroenterology and Hepatology, Fondazione IRCCS C{\`a} Granda Ospedale Maggiore Policlinico, Universit{\`a} degli Studi di Milano, Via Francesco Sforza 35, Italy; email: roberta.dambrosio@policlinico.mi.it",
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T1 - Real-world effectiveness and safety of glecaprevir/pibrentasvir in 723 patients with chronic hepatitis C

AU - D'Ambrosio, R.

AU - Pasulo, L.

AU - Puoti, M.

AU - Vinci, M.

AU - Schiavini, M.

AU - Lazzaroni, S.

AU - Soria, A.

AU - Gatti, F.

AU - Menzaghi, B.

AU - Aghemo, A.

AU - Capelli, F.

AU - Rumi, M.G.

AU - Morini, L.

AU - Giorgini, A.

AU - Pigozzi, M.G.

AU - Rossini, A.

AU - Maggiolo, F.

AU - Pan, A.

AU - Memoli, M.

AU - Spinelli, O.

AU - Del Poggio, P.

AU - Saladino, V.

AU - Spinetti, A.

AU - De Bona, A.

AU - Capretti, A.

AU - Uberti-Foppa, C.

AU - Bonfanti, P.

AU - Terreni, N.

AU - Menozzi, F.

AU - Colombo, A.E.

AU - Giglio, O.

AU - Centenaro, R.

AU - Borghi, M.

AU - Baiguera, C.

AU - Picciotto, V.

AU - Landonio, S.

AU - Gori, A.

AU - Magnani, C.

AU - Noventa, F.

AU - Paolucci, S.

AU - Lampertico, P.

AU - Fagiuoli, S.

N1 - Export Date: 1 July 2019 CODEN: JOHEE Correspondence Address: D'Ambrosio, R.; CRC “AM e A Migliavacca” Center for Liver Diseases, Division of Gastroenterology and Hepatology, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Università degli Studi di Milano, Via Francesco Sforza 35, Italy; email: roberta.dambrosio@policlinico.mi.it

PY - 2019

Y1 - 2019

KW - DAA

KW - Effectiveness

KW - Glecaprevir

KW - HCV

KW - Pibrentasvir

KW - RAS

KW - Real-life

KW - Safety

KW - SVR

KW - bilirubin

KW - glecaprevir plus pibrentasvir

KW - interferon

KW - virus RNA

KW - adult

KW - aged

KW - Article

KW - chronic hepatitis C

KW - chronic kidney failure

KW - clinical effectiveness

KW - cohort analysis

KW - depression

KW - drug safety

KW - drug tolerability

KW - drug withdrawal

KW - estimated glomerular filtration rate

KW - fatigue

KW - female

KW - headache

KW - Hepatitis C virus genotype 1

KW - Hepatitis C virus genotype 2

KW - Hepatitis C virus genotype 3

KW - human

KW - Human immunodeficiency virus infection

KW - hypertensive crisis

KW - insomnia

KW - intention to treat analysis

KW - jaundice

KW - liver stiffness

KW - longitudinal study

KW - major clinical study

KW - male

KW - mixed infection

KW - multicenter study (topic)

KW - nausea

KW - nonhuman

KW - patient compliance

KW - platelet count

KW - priority journal

KW - pruritus

KW - relapse

KW - retrospective study

KW - side effect

KW - sustained virologic response

KW - treatment duration

KW - treatment response

KW - vomiting

U2 - 10.1016/j.jhep.2018.11.011

DO - 10.1016/j.jhep.2018.11.011

M3 - Article

VL - 70

SP - 379

EP - 387

JO - Journal of Hepatology

JF - Journal of Hepatology

SN - 0168-8278

IS - 3

ER -