Real-world outcome of coronary bifurcation lesions in the drug-eluting stent era: Results from the 4,314-patient Italian Society of Invasive Cardiology (SICI-GISE) Italian Multicenter Registry on Bifurcations (I-BIGIS)

Enrico Romagnoli, Stefano De Servi, Corrado Tamburino, Antonio Colombo, Francesco Burzotta, Patrizia Presbitero, Leonardo Bolognese, Leonardo Paloscia, Paolo Rubino, Gennaro Sardella, Carlo Briguori, Federica Ettori, Gianfranco Franco, Domenico Di Girolamo, Imad Sheiban, Luigi Piatti, Cesare Greco, Sonia Petronio, Bruno Loi, Ernesto LioyAlberto Benassi, Aldo Patti, Achille Gaspardone, Davide Capodanno, Giuseppe G L Biondi-Zoccai, Giuseppe Sangiorgi

Research output: Contribution to journalArticle

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Abstract

Background: Drug-eluting stents (DESs) introduction has somewhat renewed the issues of strategy and stenting technique for treatment of bifurcation lesions. In particular, concerns remain on extensive use of DESs, especially in the side branch, and on time of dual antiplatelet therapy (DAT) discontinuation, reflecting lack of pertinent long-term data. This study aimed to evaluate clinical safety and efficacy of different strategies for bifurcations treatment in a large observational real-world registry. Methods: A multicenter, retrospective Italian study of consecutive patients undergoing bifurcation percutaneous coronary intervention between January 2002 and December 2006 was performed. The primary end point was the long-term rate of major adverse cardiac events (MACEs). The role of DAT length on outcome was also analyzed. Results: A total of 4,314 patients (4,487 lesions) were enrolled at 22 independent centers. In-hospital procedural success rate was 98.7%. After median follow-up of 24 months, MACEs occurred in 17.7%, with cardiac death in 3.4%, myocardial infarction in 4.0%, target lesion revascularization in 13.2%, and stent thrombosis in 2.9%. Extensive multivariable analysis showed that MACEs were independently predicted by age, diabetes, renal failure, systolic dysfunction, multivessel disease, myocardial infarction at admission, restenotic lesion, bare-metal stent implantation, complex stenting strategy, and short duration of DAT. Conclusions: This large study based on current clinical practice in an unselected patient population presenting with bifurcation disease and submitted to percutaneous coronary intervention demonstrated favorable long-term clinical results in this challenging patient setting, especially when DESs, simple stenting strategy, and DAT for at least 6 months are used.

Original languageEnglish
JournalAmerican Heart Journal
Volume160
Issue number3
DOIs
Publication statusPublished - 2010

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Drug-Eluting Stents
Cardiology
Registries
Percutaneous Coronary Intervention
Stents
Therapeutics
Myocardial Infarction
Renal Insufficiency
Thrombosis
Retrospective Studies
Metals
Safety
Population

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Medicine(all)

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Real-world outcome of coronary bifurcation lesions in the drug-eluting stent era : Results from the 4,314-patient Italian Society of Invasive Cardiology (SICI-GISE) Italian Multicenter Registry on Bifurcations (I-BIGIS). / Romagnoli, Enrico; De Servi, Stefano; Tamburino, Corrado; Colombo, Antonio; Burzotta, Francesco; Presbitero, Patrizia; Bolognese, Leonardo; Paloscia, Leonardo; Rubino, Paolo; Sardella, Gennaro; Briguori, Carlo; Ettori, Federica; Franco, Gianfranco; Di Girolamo, Domenico; Sheiban, Imad; Piatti, Luigi; Greco, Cesare; Petronio, Sonia; Loi, Bruno; Lioy, Ernesto; Benassi, Alberto; Patti, Aldo; Gaspardone, Achille; Capodanno, Davide; Biondi-Zoccai, Giuseppe G L; Sangiorgi, Giuseppe.

In: American Heart Journal, Vol. 160, No. 3, 2010.

Research output: Contribution to journalArticle

Romagnoli, E, De Servi, S, Tamburino, C, Colombo, A, Burzotta, F, Presbitero, P, Bolognese, L, Paloscia, L, Rubino, P, Sardella, G, Briguori, C, Ettori, F, Franco, G, Di Girolamo, D, Sheiban, I, Piatti, L, Greco, C, Petronio, S, Loi, B, Lioy, E, Benassi, A, Patti, A, Gaspardone, A, Capodanno, D, Biondi-Zoccai, GGL & Sangiorgi, G 2010, 'Real-world outcome of coronary bifurcation lesions in the drug-eluting stent era: Results from the 4,314-patient Italian Society of Invasive Cardiology (SICI-GISE) Italian Multicenter Registry on Bifurcations (I-BIGIS)', American Heart Journal, vol. 160, no. 3. https://doi.org/10.1016/j.ahj.2010.06.028
Romagnoli, Enrico ; De Servi, Stefano ; Tamburino, Corrado ; Colombo, Antonio ; Burzotta, Francesco ; Presbitero, Patrizia ; Bolognese, Leonardo ; Paloscia, Leonardo ; Rubino, Paolo ; Sardella, Gennaro ; Briguori, Carlo ; Ettori, Federica ; Franco, Gianfranco ; Di Girolamo, Domenico ; Sheiban, Imad ; Piatti, Luigi ; Greco, Cesare ; Petronio, Sonia ; Loi, Bruno ; Lioy, Ernesto ; Benassi, Alberto ; Patti, Aldo ; Gaspardone, Achille ; Capodanno, Davide ; Biondi-Zoccai, Giuseppe G L ; Sangiorgi, Giuseppe. / Real-world outcome of coronary bifurcation lesions in the drug-eluting stent era : Results from the 4,314-patient Italian Society of Invasive Cardiology (SICI-GISE) Italian Multicenter Registry on Bifurcations (I-BIGIS). In: American Heart Journal. 2010 ; Vol. 160, No. 3.
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abstract = "Background: Drug-eluting stents (DESs) introduction has somewhat renewed the issues of strategy and stenting technique for treatment of bifurcation lesions. In particular, concerns remain on extensive use of DESs, especially in the side branch, and on time of dual antiplatelet therapy (DAT) discontinuation, reflecting lack of pertinent long-term data. This study aimed to evaluate clinical safety and efficacy of different strategies for bifurcations treatment in a large observational real-world registry. Methods: A multicenter, retrospective Italian study of consecutive patients undergoing bifurcation percutaneous coronary intervention between January 2002 and December 2006 was performed. The primary end point was the long-term rate of major adverse cardiac events (MACEs). The role of DAT length on outcome was also analyzed. Results: A total of 4,314 patients (4,487 lesions) were enrolled at 22 independent centers. In-hospital procedural success rate was 98.7{\%}. After median follow-up of 24 months, MACEs occurred in 17.7{\%}, with cardiac death in 3.4{\%}, myocardial infarction in 4.0{\%}, target lesion revascularization in 13.2{\%}, and stent thrombosis in 2.9{\%}. Extensive multivariable analysis showed that MACEs were independently predicted by age, diabetes, renal failure, systolic dysfunction, multivessel disease, myocardial infarction at admission, restenotic lesion, bare-metal stent implantation, complex stenting strategy, and short duration of DAT. Conclusions: This large study based on current clinical practice in an unselected patient population presenting with bifurcation disease and submitted to percutaneous coronary intervention demonstrated favorable long-term clinical results in this challenging patient setting, especially when DESs, simple stenting strategy, and DAT for at least 6 months are used.",
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T1 - Real-world outcome of coronary bifurcation lesions in the drug-eluting stent era

T2 - Results from the 4,314-patient Italian Society of Invasive Cardiology (SICI-GISE) Italian Multicenter Registry on Bifurcations (I-BIGIS)

AU - Romagnoli, Enrico

AU - De Servi, Stefano

AU - Tamburino, Corrado

AU - Colombo, Antonio

AU - Burzotta, Francesco

AU - Presbitero, Patrizia

AU - Bolognese, Leonardo

AU - Paloscia, Leonardo

AU - Rubino, Paolo

AU - Sardella, Gennaro

AU - Briguori, Carlo

AU - Ettori, Federica

AU - Franco, Gianfranco

AU - Di Girolamo, Domenico

AU - Sheiban, Imad

AU - Piatti, Luigi

AU - Greco, Cesare

AU - Petronio, Sonia

AU - Loi, Bruno

AU - Lioy, Ernesto

AU - Benassi, Alberto

AU - Patti, Aldo

AU - Gaspardone, Achille

AU - Capodanno, Davide

AU - Biondi-Zoccai, Giuseppe G L

AU - Sangiorgi, Giuseppe

PY - 2010

Y1 - 2010

N2 - Background: Drug-eluting stents (DESs) introduction has somewhat renewed the issues of strategy and stenting technique for treatment of bifurcation lesions. In particular, concerns remain on extensive use of DESs, especially in the side branch, and on time of dual antiplatelet therapy (DAT) discontinuation, reflecting lack of pertinent long-term data. This study aimed to evaluate clinical safety and efficacy of different strategies for bifurcations treatment in a large observational real-world registry. Methods: A multicenter, retrospective Italian study of consecutive patients undergoing bifurcation percutaneous coronary intervention between January 2002 and December 2006 was performed. The primary end point was the long-term rate of major adverse cardiac events (MACEs). The role of DAT length on outcome was also analyzed. Results: A total of 4,314 patients (4,487 lesions) were enrolled at 22 independent centers. In-hospital procedural success rate was 98.7%. After median follow-up of 24 months, MACEs occurred in 17.7%, with cardiac death in 3.4%, myocardial infarction in 4.0%, target lesion revascularization in 13.2%, and stent thrombosis in 2.9%. Extensive multivariable analysis showed that MACEs were independently predicted by age, diabetes, renal failure, systolic dysfunction, multivessel disease, myocardial infarction at admission, restenotic lesion, bare-metal stent implantation, complex stenting strategy, and short duration of DAT. Conclusions: This large study based on current clinical practice in an unselected patient population presenting with bifurcation disease and submitted to percutaneous coronary intervention demonstrated favorable long-term clinical results in this challenging patient setting, especially when DESs, simple stenting strategy, and DAT for at least 6 months are used.

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