Reality orientation therapy combined with cholinesterase inhibitors in Alzheimer's disease: Randomised controlled trial

Graziano Onder, Orazio Zanetti, Ezio Giacobini, Giovanni B. Frisoni, Luisa Bartorelli, Gabriele Carbone, Paola Lambertucci, Maria Caterina Silveri, Roberto Bernabei

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Reality orientation therapy combined with cholinesterase inhibitors has not been evaluated in patients with Alzheimers disease. Aims: To perform such an evaluation. Method: We randomly assigned 79 of 156 patients treated with donepezil to receive a reality orientation programme. Caregivers of the treatment group were trained to offer the programme at home 3 days a week, 30 min/day, for 25 consecutive weeks, and were invited to stimulate and involve patients in reality-based communication. Results: The treatment group showed a slight improvement in Mini-Mental State Examination (MMSE) scores (mean change +0.2, s.e.=0.4) compared with a decline in the control group (mean change -1.1, s.e.=0.4; P=0.02). Similarly for the Alzheimers Disease Assessment Scale - Cognition (treatment group mean change +0.4, s.e.=0.8; control group -2.5, s.e.=0.8; P=001). The intervention had an equal effect on cognition in those with mild (MMSE score ≥20) and moderate (score

Original languageEnglish
Pages (from-to)450-455
Number of pages6
JournalBritish Journal of Psychiatry
Volume187
Issue numberNOV.
DOIs
Publication statusPublished - Nov 2005

ASJC Scopus subject areas

  • Neuroscience(all)
  • Psychiatry and Mental health

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