Abstract
We have recently characterized a gene fusion and chimeric protein product formed by L-myc and part of a novel gene named rlf in two small-cell lung cancer (SCLC) cell lines. The rlf-L-myc fusion gene is formed by intrachromosomal rearrangements placing the regulatory region and (at least) the first exon of rlf upstream of the L-myc gene. In the characterized cases the fusion gene has also been involved in DNA amplification. Here we report on a similar in vivo rearrangement involving rlf and L-myc in a primary SCLC tumor. In addition, we have found co-amplification of L-myc and rlf without visible rearrangements in either gene in three other SCLC tumors, confirming the physical linkage of these loci.
Original language | English |
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Pages (from-to) | 405-409 |
Number of pages | 5 |
Journal | Oncogene |
Volume | 7 |
Issue number | 3 |
Publication status | Published - Mar 1992 |
ASJC Scopus subject areas
- Molecular Biology
- Cancer Research
- Genetics