Rearrangement of nuclear ribonucleoprotein (RNP)-containing structures during apoptosis and transcriptional arrest

Marco Biggiogera, Maria Grazia Bottone, Anna Ivana Scovassi, Cristiana Soldani, Lorella Vecchio, Carlo Pellicciari

Research output: Contribution to journalArticlepeer-review


The aim of this paper is to review the data in the literature concerning ribonucleoprotein components during apoptosis, where a major rearrangement of RNPs takes place. In parallel with chromatin changes, the nucleoplasmic constituents (perichromatin fibrils; perichromatin granules; interchromatin granules and nuclear bodies) as well as the nucleoli aggregate into heterogeneous clusters called HERDS, in the interchromatin space. Later, these RNP-containing structures are extruded from the nucleus and leave the cell within cytoplasmic blebs. We propose also a role for HERDS as markers of irreversible transcriptional arrest.

Original languageEnglish
Pages (from-to)603-615
Number of pages13
JournalBiology of the cell / under the auspices of the European Cell Biology Organization
Issue number8
Publication statusPublished - Oct 2004


  • Electron microscopy
  • Immunocytochemistry
  • Nuclear ribonucleoproteins
  • Transcription

ASJC Scopus subject areas

  • Cell Biology


Dive into the research topics of 'Rearrangement of nuclear ribonucleoprotein (RNP)-containing structures during apoptosis and transcriptional arrest'. Together they form a unique fingerprint.

Cite this