Abstract
TRK oncogenes are observed in a consistent fraction of papillary thyroid carcinoma (PTC); they arise from the fusion of the 3′ terminal sequences of the NTRK1/. NGF receptor gene with 5′ terminal sequences of various activating genes, such as TPM3, TPR and TFG. TRK oncoproteins display constitutive tyrosine-kinase activity, leading to in vitro and in vivo transformation. In this review studies performed during the last 20 years will be summarized. The following topics will be illustrated: (a) frequency of TRK oncogenes and correlation with radiation and tumor histopathological features; (b) molecular mechanisms underlying NTRK1 oncogenic rearrangements; (c) molecular and biochemical characterization of TRK oncoproteins, and their mechanism of action; (d) role of activating sequences in the activation of TRK oncoproteins.
Original language | English |
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Pages (from-to) | 44-49 |
Number of pages | 6 |
Journal | Molecular and Cellular Endocrinology |
Volume | 321 |
Issue number | 1 |
DOIs | |
Publication status | Published - May 2010 |
Keywords
- Gene rearrangement
- NTRK1
- Papillary thyroid tumor
ASJC Scopus subject areas
- Biochemistry
- Endocrinology
- Molecular Biology