Rearrangements of NTRK1 gene in papillary thyroid carcinoma

A. Greco, C. Miranda, M. A. Pierotti

Research output: Contribution to journalArticle

Abstract

TRK oncogenes are observed in a consistent fraction of papillary thyroid carcinoma (PTC); they arise from the fusion of the 3′ terminal sequences of the NTRK1/. NGF receptor gene with 5′ terminal sequences of various activating genes, such as TPM3, TPR and TFG. TRK oncoproteins display constitutive tyrosine-kinase activity, leading to in vitro and in vivo transformation. In this review studies performed during the last 20 years will be summarized. The following topics will be illustrated: (a) frequency of TRK oncogenes and correlation with radiation and tumor histopathological features; (b) molecular mechanisms underlying NTRK1 oncogenic rearrangements; (c) molecular and biochemical characterization of TRK oncoproteins, and their mechanism of action; (d) role of activating sequences in the activation of TRK oncoproteins.

Original languageEnglish
Pages (from-to)44-49
Number of pages6
JournalMolecular and Cellular Endocrinology
Volume321
Issue number1
DOIs
Publication statusPublished - May 2010

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Keywords

  • Gene rearrangement
  • NTRK1
  • Papillary thyroid tumor

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Molecular Biology

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