Rearrangements of NTRK1 gene in papillary thyroid carcinoma

A. Greco; C. Miranda; M. A. Pierotti

doi:10.1016/j.mce.2009.10.009

Rearrangements of NTRK1 gene in papillary thyroid carcinoma

A. Greco, C. Miranda, M. A. Pierotti

Fondazione IRCCS Istituto Nazionale dei Tumori

Research output: Contribution to journal › Article

Abstract

TRK oncogenes are observed in a consistent fraction of papillary thyroid carcinoma (PTC); they arise from the fusion of the 3′ terminal sequences of the NTRK1/. NGF receptor gene with 5′ terminal sequences of various activating genes, such as TPM3, TPR and TFG. TRK oncoproteins display constitutive tyrosine-kinase activity, leading to in vitro and in vivo transformation. In this review studies performed during the last 20 years will be summarized. The following topics will be illustrated: (a) frequency of TRK oncogenes and correlation with radiation and tumor histopathological features; (b) molecular mechanisms underlying NTRK1 oncogenic rearrangements; (c) molecular and biochemical characterization of TRK oncoproteins, and their mechanism of action; (d) role of activating sequences in the activation of TRK oncoproteins.

Original language	English
Pages (from-to)	44-49
Number of pages	6
Journal	Molecular and Cellular Endocrinology
Volume	321
Issue number	1
DOIs	https://doi.org/10.1016/j.mce.2009.10.009
Publication status	Published - May 2010

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Keywords

Gene rearrangement
NTRK1
Papillary thyroid tumor

ASJC Scopus subject areas

Biochemistry
Endocrinology
Molecular Biology

Cite this

Greco, A., Miranda, C., & Pierotti, M. A. (2010). Rearrangements of NTRK1 gene in papillary thyroid carcinoma. Molecular and Cellular Endocrinology, 321(1), 44-49. https://doi.org/10.1016/j.mce.2009.10.009

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10.1016/j.mce.2009.10.009