Rearrangements of NTRK1 gene in papillary thyroid carcinoma

A. Greco; C. Miranda; M. A. Pierotti

doi:10.1016/j.mce.2009.10.009

Rearrangements of NTRK1 gene in papillary thyroid carcinoma

A. Greco, C. Miranda, M. A. Pierotti

Fondazione IRCCS Istituto Nazionale dei Tumori

Research output: Contribution to journal › Article › peer-review

Abstract

TRK oncogenes are observed in a consistent fraction of papillary thyroid carcinoma (PTC); they arise from the fusion of the 3′ terminal sequences of the NTRK1/. NGF receptor gene with 5′ terminal sequences of various activating genes, such as TPM3, TPR and TFG. TRK oncoproteins display constitutive tyrosine-kinase activity, leading to in vitro and in vivo transformation. In this review studies performed during the last 20 years will be summarized. The following topics will be illustrated: (a) frequency of TRK oncogenes and correlation with radiation and tumor histopathological features; (b) molecular mechanisms underlying NTRK1 oncogenic rearrangements; (c) molecular and biochemical characterization of TRK oncoproteins, and their mechanism of action; (d) role of activating sequences in the activation of TRK oncoproteins.

Original language	English
Pages (from-to)	44-49
Number of pages	6
Journal	Molecular and Cellular Endocrinology
Volume	321
Issue number	1
DOIs	https://doi.org/10.1016/j.mce.2009.10.009
Publication status	Published - May 2010

Keywords

Gene rearrangement
NTRK1
Papillary thyroid tumor

ASJC Scopus subject areas

Biochemistry
Endocrinology
Molecular Biology

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10.1016/j.mce.2009.10.009

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abstract = "TRK oncogenes are observed in a consistent fraction of papillary thyroid carcinoma (PTC); they arise from the fusion of the 3′ terminal sequences of the NTRK1/. NGF receptor gene with 5′ terminal sequences of various activating genes, such as TPM3, TPR and TFG. TRK oncoproteins display constitutive tyrosine-kinase activity, leading to in vitro and in vivo transformation. In this review studies performed during the last 20 years will be summarized. The following topics will be illustrated: (a) frequency of TRK oncogenes and correlation with radiation and tumor histopathological features; (b) molecular mechanisms underlying NTRK1 oncogenic rearrangements; (c) molecular and biochemical characterization of TRK oncoproteins, and their mechanism of action; (d) role of activating sequences in the activation of TRK oncoproteins.",

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T1 - Rearrangements of NTRK1 gene in papillary thyroid carcinoma

AU - Greco, A.

AU - Miranda, C.

AU - Pierotti, M. A.

PY - 2010/5

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N2 - TRK oncogenes are observed in a consistent fraction of papillary thyroid carcinoma (PTC); they arise from the fusion of the 3′ terminal sequences of the NTRK1/. NGF receptor gene with 5′ terminal sequences of various activating genes, such as TPM3, TPR and TFG. TRK oncoproteins display constitutive tyrosine-kinase activity, leading to in vitro and in vivo transformation. In this review studies performed during the last 20 years will be summarized. The following topics will be illustrated: (a) frequency of TRK oncogenes and correlation with radiation and tumor histopathological features; (b) molecular mechanisms underlying NTRK1 oncogenic rearrangements; (c) molecular and biochemical characterization of TRK oncoproteins, and their mechanism of action; (d) role of activating sequences in the activation of TRK oncoproteins.

AB - TRK oncogenes are observed in a consistent fraction of papillary thyroid carcinoma (PTC); they arise from the fusion of the 3′ terminal sequences of the NTRK1/. NGF receptor gene with 5′ terminal sequences of various activating genes, such as TPM3, TPR and TFG. TRK oncoproteins display constitutive tyrosine-kinase activity, leading to in vitro and in vivo transformation. In this review studies performed during the last 20 years will be summarized. The following topics will be illustrated: (a) frequency of TRK oncogenes and correlation with radiation and tumor histopathological features; (b) molecular mechanisms underlying NTRK1 oncogenic rearrangements; (c) molecular and biochemical characterization of TRK oncoproteins, and their mechanism of action; (d) role of activating sequences in the activation of TRK oncoproteins.

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Rearrangements of NTRK1 gene in papillary thyroid carcinoma

Abstract

Keywords

ASJC Scopus subject areas

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