Recent advances in amyotrophic lateral sclerosis

Research output: Contribution to journalReview articlepeer-review

Abstract

ALS is a relentlessly progressive and fatal disease, with no curative therapies available to date. Symptomatic and palliative care, provided in a multidisciplinary context, still remains the cornerstone of ALS management. However, our understanding of the molecular mechanisms underlying the disease has advanced greatly over the past years, giving new hope for the development of novel diagnostic and therapeutic approaches. Here, we have reviewed the most recent studies that have contributed to improving both clinical management and our understanding of ALS pathogenesis.
Original languageEnglish
Pages (from-to)1241 - 1254
Number of pages14
JournalJournal of Neurology
Volume263
Issue number6
DOIs
Publication statusPublished - Jun 1 2016

Keywords

  • ALS genetics
  • Clinical management
  • Motor neuron disease
  • Neuroimaging
  • Pathogenesis

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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