Recent advances in cartilage repair (ICL 3)

Giuseppe M. Peretti, Peter Angele, Giuseppe Filardo, Elizaveta Kon, Laura Mangiavini, Antongiulio Marmotti, Silvia Mattia, Konrad Slynarski, Francesc Soler, Dieter Van Assche, Henning Madry

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Articular cartilage possesses low intrinsic healing property due to its lack of vascularity and progenitor cells. Thus, damage to the hyaline cartilage may lead to a progressive degeneration of the joint and eventually to osteoarthritis (OA). In the last years, different surgical techniques have been introduced in the clinical practice to overcome this issue. Bone marrow stimulation, for example, is a widely known method to allow cell invasion from the bloodstream to the site of damage. However, the reparative tissue has different morphological and biomechanical properties when compared to the native cartilage. In particular, the newly formed fibrocartilage has a low amount of proteoglycans and a higher concentration of type I collagen. This different matrix composition leads to a decrease in the mechanical strength and to a poor integration of the reparative tissue with the native cartilage.

Original languageEnglish
Title of host publicationESSKA Instructional Course Lecture Book: Barcelona 2016
PublisherSpringer Berlin Heidelberg
Pages27-42
Number of pages16
ISBN (Electronic)9783662491140
ISBN (Print)9783662491133
DOIs
Publication statusPublished - Jan 1 2016

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ASJC Scopus subject areas

  • Medicine(all)

Cite this

Peretti, G. M., Angele, P., Filardo, G., Kon, E., Mangiavini, L., Marmotti, A., Mattia, S., Slynarski, K., Soler, F., Van Assche, D., & Madry, H. (2016). Recent advances in cartilage repair (ICL 3). In ESSKA Instructional Course Lecture Book: Barcelona 2016 (pp. 27-42). Springer Berlin Heidelberg. https://doi.org/10.1007/978-3-662-49114-0_3