Recent advances in iron metabolism and related disorders

Clara Camaschella, Paolo Strati

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Iron is essential for life, because it is indispensable for several biological reactions such as oxygen transport, DNA synthesis and cell proliferation, but is toxic if present in excess since it causes cellular damage through free radical formation. Either cellular or systemic iron regulation can be disrupted in disorders of iron metabolism. In the past few years, our understanding of iron metabolism and its regulation has dramatically changed. New disorders of iron metabolism have emerged and the role of iron has started to be recognized as a cofactor of other disorders. The study of genetic conditions such as hemochromatosis and iron-refractory-iron-deficiency anemia (IRIDA) has provided crucial insights into the molecular mechanisms controlling iron homeostasis. In the future, these advances may be exploited for a more effective treatment of both genetic and acquired iron disorders.

Original languageEnglish
Pages (from-to)393-400
Number of pages8
JournalInternal and Emergency Medicine
Volume5
Issue number5
DOIs
Publication statusPublished - 2010

Fingerprint

Iron Metabolism Disorders
Iron
Hemochromatosis
Poisons
Free Radicals
Homeostasis
Cell Proliferation
Oxygen
DNA

Keywords

  • Hemochromatosis
  • Hepcidin
  • Hyperferritinemia
  • Iron deficiency
  • Iron metabolism

ASJC Scopus subject areas

  • Emergency Medicine
  • Internal Medicine

Cite this

Recent advances in iron metabolism and related disorders. / Camaschella, Clara; Strati, Paolo.

In: Internal and Emergency Medicine, Vol. 5, No. 5, 2010, p. 393-400.

Research output: Contribution to journalArticle

@article{ad463db6570744f4bd31796269107692,
title = "Recent advances in iron metabolism and related disorders",
abstract = "Iron is essential for life, because it is indispensable for several biological reactions such as oxygen transport, DNA synthesis and cell proliferation, but is toxic if present in excess since it causes cellular damage through free radical formation. Either cellular or systemic iron regulation can be disrupted in disorders of iron metabolism. In the past few years, our understanding of iron metabolism and its regulation has dramatically changed. New disorders of iron metabolism have emerged and the role of iron has started to be recognized as a cofactor of other disorders. The study of genetic conditions such as hemochromatosis and iron-refractory-iron-deficiency anemia (IRIDA) has provided crucial insights into the molecular mechanisms controlling iron homeostasis. In the future, these advances may be exploited for a more effective treatment of both genetic and acquired iron disorders.",
keywords = "Hemochromatosis, Hepcidin, Hyperferritinemia, Iron deficiency, Iron metabolism",
author = "Clara Camaschella and Paolo Strati",
year = "2010",
doi = "10.1007/s11739-010-0387-4",
language = "English",
volume = "5",
pages = "393--400",
journal = "Internal and Emergency Medicine",
issn = "1828-0447",
publisher = "Springer-Verlag Italia s.r.l.",
number = "5",

}

TY - JOUR

T1 - Recent advances in iron metabolism and related disorders

AU - Camaschella, Clara

AU - Strati, Paolo

PY - 2010

Y1 - 2010

N2 - Iron is essential for life, because it is indispensable for several biological reactions such as oxygen transport, DNA synthesis and cell proliferation, but is toxic if present in excess since it causes cellular damage through free radical formation. Either cellular or systemic iron regulation can be disrupted in disorders of iron metabolism. In the past few years, our understanding of iron metabolism and its regulation has dramatically changed. New disorders of iron metabolism have emerged and the role of iron has started to be recognized as a cofactor of other disorders. The study of genetic conditions such as hemochromatosis and iron-refractory-iron-deficiency anemia (IRIDA) has provided crucial insights into the molecular mechanisms controlling iron homeostasis. In the future, these advances may be exploited for a more effective treatment of both genetic and acquired iron disorders.

AB - Iron is essential for life, because it is indispensable for several biological reactions such as oxygen transport, DNA synthesis and cell proliferation, but is toxic if present in excess since it causes cellular damage through free radical formation. Either cellular or systemic iron regulation can be disrupted in disorders of iron metabolism. In the past few years, our understanding of iron metabolism and its regulation has dramatically changed. New disorders of iron metabolism have emerged and the role of iron has started to be recognized as a cofactor of other disorders. The study of genetic conditions such as hemochromatosis and iron-refractory-iron-deficiency anemia (IRIDA) has provided crucial insights into the molecular mechanisms controlling iron homeostasis. In the future, these advances may be exploited for a more effective treatment of both genetic and acquired iron disorders.

KW - Hemochromatosis

KW - Hepcidin

KW - Hyperferritinemia

KW - Iron deficiency

KW - Iron metabolism

UR - http://www.scopus.com/inward/record.url?scp=77956874149&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77956874149&partnerID=8YFLogxK

U2 - 10.1007/s11739-010-0387-4

DO - 10.1007/s11739-010-0387-4

M3 - Article

VL - 5

SP - 393

EP - 400

JO - Internal and Emergency Medicine

JF - Internal and Emergency Medicine

SN - 1828-0447

IS - 5

ER -