Recent advances in searching c-Myc transcriptional cofactors during tumorigenesis

Matteo Caforio; Cristina Sorino; Stefano Iacovelli; Maurizio Fanciulli; Franco Locatelli; Valentina Folgiero

doi:10.1186/s13046-018-0912-2

Recent advances in searching c-Myc transcriptional cofactors during tumorigenesis

Matteo Caforio, Cristina Sorino, Stefano Iacovelli, Maurizio Fanciulli, Franco Locatelli, Valentina Folgiero

Research output: Contribution to journal › Review article › peer-review

Abstract

BACKGROUND: The mechanism by which c-Myc exerts its oncogenic functions is not completely clear and different hypotheses are still under investigation. The knowledge of the capacity of c-Myc to bind exclusively E-box sequences determined the discrepancy between, on the one hand, genomic studies showing the binding of c-Myc to all active promoters and, on the other hand, the evidence that only 60% or less of the binding sites have E-box sequences.

MAIN BODY: In this review, we provide support to the hypothesis that the cooperation of c-Myc with transcriptional cofactors mediates c-Myc-induced cellular functions. We produce evidence that recently identified cofactors are involved in c-Myc control of survival mechanisms of cancer cells.

CONCLUSION: The identification of new c-Myc cofactors could favor the development of therapeutic strategies able to compensate the difficulty of targeting c-Myc.

Original language	English
Pages (from-to)	239
Journal	Journal of Experimental and Clinical Cancer Research
Volume	37
Issue number	1
DOIs	https://doi.org/10.1186/s13046-018-0912-2
Publication status	Published - Sep 27 2018

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title = "Recent advances in searching c-Myc transcriptional cofactors during tumorigenesis",

abstract = "BACKGROUND: The mechanism by which c-Myc exerts its oncogenic functions is not completely clear and different hypotheses are still under investigation. The knowledge of the capacity of c-Myc to bind exclusively E-box sequences determined the discrepancy between, on the one hand, genomic studies showing the binding of c-Myc to all active promoters and, on the other hand, the evidence that only 60% or less of the binding sites have E-box sequences.MAIN BODY: In this review, we provide support to the hypothesis that the cooperation of c-Myc with transcriptional cofactors mediates c-Myc-induced cellular functions. We produce evidence that recently identified cofactors are involved in c-Myc control of survival mechanisms of cancer cells.CONCLUSION: The identification of new c-Myc cofactors could favor the development of therapeutic strategies able to compensate the difficulty of targeting c-Myc.",

author = "Matteo Caforio and Cristina Sorino and Stefano Iacovelli and Maurizio Fanciulli and Franco Locatelli and Valentina Folgiero",

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TY - JOUR

T1 - Recent advances in searching c-Myc transcriptional cofactors during tumorigenesis

AU - Caforio, Matteo

AU - Sorino, Cristina

AU - Iacovelli, Stefano

AU - Fanciulli, Maurizio

AU - Locatelli, Franco

AU - Folgiero, Valentina

PY - 2018/9/27

Y1 - 2018/9/27

N2 - BACKGROUND: The mechanism by which c-Myc exerts its oncogenic functions is not completely clear and different hypotheses are still under investigation. The knowledge of the capacity of c-Myc to bind exclusively E-box sequences determined the discrepancy between, on the one hand, genomic studies showing the binding of c-Myc to all active promoters and, on the other hand, the evidence that only 60% or less of the binding sites have E-box sequences.MAIN BODY: In this review, we provide support to the hypothesis that the cooperation of c-Myc with transcriptional cofactors mediates c-Myc-induced cellular functions. We produce evidence that recently identified cofactors are involved in c-Myc control of survival mechanisms of cancer cells.CONCLUSION: The identification of new c-Myc cofactors could favor the development of therapeutic strategies able to compensate the difficulty of targeting c-Myc.

AB - BACKGROUND: The mechanism by which c-Myc exerts its oncogenic functions is not completely clear and different hypotheses are still under investigation. The knowledge of the capacity of c-Myc to bind exclusively E-box sequences determined the discrepancy between, on the one hand, genomic studies showing the binding of c-Myc to all active promoters and, on the other hand, the evidence that only 60% or less of the binding sites have E-box sequences.MAIN BODY: In this review, we provide support to the hypothesis that the cooperation of c-Myc with transcriptional cofactors mediates c-Myc-induced cellular functions. We produce evidence that recently identified cofactors are involved in c-Myc control of survival mechanisms of cancer cells.CONCLUSION: The identification of new c-Myc cofactors could favor the development of therapeutic strategies able to compensate the difficulty of targeting c-Myc.

U2 - 10.1186/s13046-018-0912-2

DO - 10.1186/s13046-018-0912-2

M3 - Review article

C2 - 30261904

VL - 37

SP - 239

JO - Journal of Experimental and Clinical Cancer Research

JF - Journal of Experimental and Clinical Cancer Research

SN - 0392-9078

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