Recent advances in targeted anti-vasculature therapy: The neuroblastoma model

F. Pastorino, D. Di Paolo, M. Loi, P. Becherini, I. Caffa, A. Zorzoli, D. Marimpietri, R. Carosio, P. Perri, P. G. Montaldo, C. Brignole, G. Pagnan, D. Ribatti, T. M. Allen, M. Ponzoni

Research output: Contribution to journalArticlepeer-review

Abstract

Novel anti-vasculature strategies that are emerging for the treatment of cancer and for the inhibition of angiogenesis may be a promising new tool for the adjuvant therapy of malignant tumours. Over the last fifteen years, several reports have been published concerning the relationship between tumour progression and angiogenesis in experimental models of neuroblastoma in vitro and in vivo. Moreover, a high vascular index in neuroblastoma correlates with poor prognosis, suggesting dependence of aggressive tumour growth on active angiogenesis. Here, we present an overview of the most recent advances in anti-vasculature therapy of neuroblastoma, and describe some preclinical results as well as future perspectives.

Original languageEnglish
Pages (from-to)1021-1027
Number of pages7
JournalCurrent Drug Targets
Volume10
Issue number10
DOIs
Publication statusPublished - 2009

Keywords

  • Angiogenesis
  • Anti-tumour drugs
  • Ligand-mediated targeting
  • Liposomes
  • Neuroblastoma
  • Peptides
  • Phage display

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology
  • Clinical Biochemistry
  • Molecular Medicine

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