Recent advances in the molecular landscape of lung neuroendocrine tumors

Giuseppe Pelosi, Fabrizio Bianchi, Paul Hofman, Linda Pattini, Philipp Ströbel, Fiorella Calabrese, Salma Naheed, Chloe Holden, Judith Cave, Hanibal Bohnenberger, Helen Dinter, Sergio Harari, Adriana Albini, Angelica Sonzogni, Mauro Papotti, Marco Volante, Christian H. Ottensmeier

Research output: Contribution to journalReview articlepeer-review


Introduction: Neuroendocrine tumors of the lung (Lung-NETs) make up a heterogenous family of neoplasms showing neuroendocrine differentiation and encompass carcinoids and neuroendocrine carcinomas. On molecular grounds, they considered two completely distinct and separate tumor groups with no overlap of molecular alterations nor common developmental mechanisms. Areas covered: Two perspectives were evaluated based on an extensive review and rethinking of literature: (1) the current classification as an instrument to obtaining clinical and molecular insights into the context of Lung-NETs; and (2) an alternative and innovative interpretation of these tumors, proposing a tripartite separation into early aggressive primary high-grade neuroendocrine tumors (HGNET), differentiating or secondary HGNET, and indolent NET. Expert opinion: We herein provide an alternative outlook on Lung-NETs, which is a paradigm shift to current pathogenesis models and expands the understanding of these tumors.

Original languageEnglish
Pages (from-to)281-297
Number of pages17
JournalExpert Review of Molecular Diagnostics
Issue number4
Publication statusPublished - Apr 3 2019


  • carcinoma
  • copy number variation
  • evolution
  • gene
  • genomic analysis
  • Ki-67 index
  • lung
  • mutation
  • Neuroendocrine
  • pathogenesis
  • tumor

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Medicine
  • Molecular Biology
  • Genetics


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