Recent advances in the use of Anti-TNFα therapy for the treatment of juvenile idiopathic arthritis

Andrea Taddio, Marco Cattalini, Gabriele Simonini, Rolando Cimaz

Research output: Contribution to journalArticle

Abstract

Juvenile Idiopathic Arthritis (JIA) encompasses a group of diseases of unknown etiology having in common arthritis in at least 1 joint that persists for 6 weeks and begins before 16 years of age, with other conditions excluded. With a prevalence of 1 per 1,000 children in the USA, JIA is the most common pediatric rheumatic illness and a major cause of acquired childhood disability. During the last 20 years, the advent of host immune response modifiers known as biologic agents, in particular the anti-TNFα agents (etanercept, infliximab, adalimumab), which directly inhibit the action of pro-inflammatory mediators, has revolutionized the treatment and the expected outcome of JIA. This article highlights treatment indications of anti-TNFα drugs and their more frequent side effects in JIA patients.

Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalExpert Review of Clinical Immunology
DOIs
Publication statusAccepted/In press - Feb 21 2016

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Fingerprint Dive into the research topics of 'Recent advances in the use of Anti-TNFα therapy for the treatment of juvenile idiopathic arthritis'. Together they form a unique fingerprint.

  • Cite this