Recent developments in clinical trials of botulinum neurotoxins

Research output: Contribution to journalArticle

Abstract

Botulinum neurotoxins (BoNTs) are increasingly used in clinical practice for several indications. Following the pioneering years of discoveries, the recent years have witnessed an increase of new indications and new toxin brands.We review here the clinical trials on BoNTs performed since 2014 and put them into perspective. We also review the ongoing trials listed by the National Institutes of Health registry (Clinicaltrials.gov). The following indications are reviewed here: blepharospasm, cervical dystonia, spasticity, cerebral palsy, urinary incontinence, headache, topical formulations, postoperative cardiac arrhythmia, keloids and scars. For each of these indications the latest trials are reviewed and commented.

Original languageEnglish
JournalToxicon
DOIs
Publication statusAccepted/In press - Jan 1 2017

Keywords

  • Botulinum toxins
  • Clinical trial

ASJC Scopus subject areas

  • Toxicology

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