TY - JOUR
T1 - Recent developments in the cell biology of granulocyte-macrophage colony-stimulating factor and granulocyte colony-stimulating factor
T2 - activities on endothelial cells
AU - Bussolino, Federico
AU - Colotta, Francesco
AU - Bocchietto, Elena
AU - Guglielmetti, Antonella
AU - Mantovani, Alberto
PY - 1993/12
Y1 - 1993/12
N2 - Granulocyte-macrophage colony-stimulating factor and granulocyte colony-stimulating factor were considered as growth and differentiation factors restricted to hematopoietic cells. It was recently found that non-hematopoietic cells, including endothelial cells, respond to these cytokines. In this review we describe their effects on endothelial cells, underlining their role in the behavior and survival of the microenvironment of bone marrow, in the angiogenesis process related to the progression of solid tumors and of vascular tumors, and in the homing of lymphocytes.
AB - Granulocyte-macrophage colony-stimulating factor and granulocyte colony-stimulating factor were considered as growth and differentiation factors restricted to hematopoietic cells. It was recently found that non-hematopoietic cells, including endothelial cells, respond to these cytokines. In this review we describe their effects on endothelial cells, underlining their role in the behavior and survival of the microenvironment of bone marrow, in the angiogenesis process related to the progression of solid tumors and of vascular tumors, and in the homing of lymphocytes.
KW - Angiogenesis
KW - Bone marrow
KW - Endothelium
KW - Granulocyte-colony stimulating factor
KW - Granulocyte-macrophage colony-stimulating factor
KW - Vascular tumor
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U2 - 10.1007/BF02592273
DO - 10.1007/BF02592273
M3 - Article
C2 - 7682862
AN - SCOPUS:0027350750
VL - 23
SP - 8
EP - 12
JO - Ricerca in Clinica e in Laboratorio
JF - Ricerca in Clinica e in Laboratorio
SN - 0940-5437
IS - 1-4
ER -