Recent developments in the cell biology of granulocyte-macrophage colony-stimulating factor and granulocyte colony-stimulating factor: activities on endothelial cells

Federico Bussolino, Francesco Colotta, Elena Bocchietto, Antonella Guglielmetti, Alberto Mantovani

Research output: Contribution to journalArticle


Granulocyte-macrophage colony-stimulating factor and granulocyte colony-stimulating factor were considered as growth and differentiation factors restricted to hematopoietic cells. It was recently found that non-hematopoietic cells, including endothelial cells, respond to these cytokines. In this review we describe their effects on endothelial cells, underlining their role in the behavior and survival of the microenvironment of bone marrow, in the angiogenesis process related to the progression of solid tumors and of vascular tumors, and in the homing of lymphocytes.

Original languageEnglish
Pages (from-to)8-12
Number of pages5
JournalInternational Journal of Clinical & Laboratory Research
Issue number1-4
Publication statusPublished - Dec 1993



  • Angiogenesis
  • Bone marrow
  • Endothelium
  • Granulocyte-colony stimulating factor
  • Granulocyte-macrophage colony-stimulating factor
  • Vascular tumor

ASJC Scopus subject areas

  • Clinical Biochemistry

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