Recent evidence on the role of dietary PUFAs in cancer development and prevention

Research output: Contribution to journalArticle

Abstract

During the last decades a great bulk of scientific information has been accumulated about the metabolic effects of polyunsaturated fatty acids (PUFAs) that can impact human health. In particular, a growing body of evidence from in vitro, animal, and clinical studies supporting the use of n-3 PUFAs in cancer prevention has been collected. Furthermore, a considerable effort has recently been done to evaluate the hypothesis that n-3 PUFAs might improve the efficiency of currently used anticancer drugs. The role of n-6 PUFAs, in contrast, needs to be better assessed. A high dietary intake of n-6 PUFAs has been found to be associated with an increased risk of various cancer development; however, it should be mentioned that several papers have highlighted beneficial effects of n-6 PUFAs. The effective mechanisms of action of PUFAs have not been fully clarified yet, even if the incorporation of fatty acids in cell membranes has been considered a pivotal event in modulating inflammatory processes. This review aims to report the most updated evidence on the role of n-6 and n-3 PUFAs in the development and treatment of human cancers, focusing on the potential mechanisms by which PUFAs exert their effects. Moreover, gender-associated differences in response to PUFAs treatment were pointed out.

Original languageEnglish
JournalCurrent Medicinal Chemistry
DOIs
Publication statusE-pub ahead of print - Dec 4 2017

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Unsaturated Fatty Acids
Omega-3 Fatty Acids
Neoplasms
Human Development
Cell membranes
Animals
Fatty Acids
Cell Membrane
Health
Pharmaceutical Preparations

Keywords

  • PUFAs
  • Cancer development
  • diet
  • Human health
  • nutrition
  • omega 3
  • omega 6

Cite this

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title = "Recent evidence on the role of dietary PUFAs in cancer development and prevention",
abstract = "During the last decades a great bulk of scientific information has been accumulated about the metabolic effects of polyunsaturated fatty acids (PUFAs) that can impact human health. In particular, a growing body of evidence from in vitro, animal, and clinical studies supporting the use of n-3 PUFAs in cancer prevention has been collected. Furthermore, a considerable effort has recently been done to evaluate the hypothesis that n-3 PUFAs might improve the efficiency of currently used anticancer drugs. The role of n-6 PUFAs, in contrast, needs to be better assessed. A high dietary intake of n-6 PUFAs has been found to be associated with an increased risk of various cancer development; however, it should be mentioned that several papers have highlighted beneficial effects of n-6 PUFAs. The effective mechanisms of action of PUFAs have not been fully clarified yet, even if the incorporation of fatty acids in cell membranes has been considered a pivotal event in modulating inflammatory processes. This review aims to report the most updated evidence on the role of n-6 and n-3 PUFAs in the development and treatment of human cancers, focusing on the potential mechanisms by which PUFAs exert their effects. Moreover, gender-associated differences in response to PUFAs treatment were pointed out.",
keywords = "PUFAs, Cancer development, diet, Human health, nutrition, omega 3, omega 6",
author = "Massimo D'Archivio and Beatrice Scazzocchio and Rosaria Vari and Carmela Santangelo and Claudio Giovannini and Roberta Masella",
note = "Copyright{\circledC} Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.",
year = "2017",
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T1 - Recent evidence on the role of dietary PUFAs in cancer development and prevention

AU - D'Archivio, Massimo

AU - Scazzocchio, Beatrice

AU - Vari, Rosaria

AU - Santangelo, Carmela

AU - Giovannini, Claudio

AU - Masella, Roberta

N1 - Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

PY - 2017/12/4

Y1 - 2017/12/4

N2 - During the last decades a great bulk of scientific information has been accumulated about the metabolic effects of polyunsaturated fatty acids (PUFAs) that can impact human health. In particular, a growing body of evidence from in vitro, animal, and clinical studies supporting the use of n-3 PUFAs in cancer prevention has been collected. Furthermore, a considerable effort has recently been done to evaluate the hypothesis that n-3 PUFAs might improve the efficiency of currently used anticancer drugs. The role of n-6 PUFAs, in contrast, needs to be better assessed. A high dietary intake of n-6 PUFAs has been found to be associated with an increased risk of various cancer development; however, it should be mentioned that several papers have highlighted beneficial effects of n-6 PUFAs. The effective mechanisms of action of PUFAs have not been fully clarified yet, even if the incorporation of fatty acids in cell membranes has been considered a pivotal event in modulating inflammatory processes. This review aims to report the most updated evidence on the role of n-6 and n-3 PUFAs in the development and treatment of human cancers, focusing on the potential mechanisms by which PUFAs exert their effects. Moreover, gender-associated differences in response to PUFAs treatment were pointed out.

AB - During the last decades a great bulk of scientific information has been accumulated about the metabolic effects of polyunsaturated fatty acids (PUFAs) that can impact human health. In particular, a growing body of evidence from in vitro, animal, and clinical studies supporting the use of n-3 PUFAs in cancer prevention has been collected. Furthermore, a considerable effort has recently been done to evaluate the hypothesis that n-3 PUFAs might improve the efficiency of currently used anticancer drugs. The role of n-6 PUFAs, in contrast, needs to be better assessed. A high dietary intake of n-6 PUFAs has been found to be associated with an increased risk of various cancer development; however, it should be mentioned that several papers have highlighted beneficial effects of n-6 PUFAs. The effective mechanisms of action of PUFAs have not been fully clarified yet, even if the incorporation of fatty acids in cell membranes has been considered a pivotal event in modulating inflammatory processes. This review aims to report the most updated evidence on the role of n-6 and n-3 PUFAs in the development and treatment of human cancers, focusing on the potential mechanisms by which PUFAs exert their effects. Moreover, gender-associated differences in response to PUFAs treatment were pointed out.

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