TY - JOUR
T1 - Recent highlights
T2 - Onco viral exploitation of the sumo system
AU - Mattoscio, Domenico
AU - Medda, Alessandro
AU - Chiocca, Susanna
PY - 2020/1/1
Y1 - 2020/1/1
N2 - Small ubiquitin-like modifier (SUMO)ylation is a crucial post-translational modification that controls functions of a wide collection of proteins and biological processes. Hence, given its pleiotropic role, viruses have developed many approaches to usurp SUMO conjugation to exploit the cellular host environment for their own benefit. Consistently, cancer cells also frequently impact on SUMO to force cellular transformation, underlining the importance of SUMO in health and diseases. Therefore, after a brief introduction to the multistep SUMOylation pathway, in this review we will focus our attention on several examples of strategies adopted by oncogenic viruses to hijack SUMOylation in order to promote infection, persistence and malignant transformation of host cells.
AB - Small ubiquitin-like modifier (SUMO)ylation is a crucial post-translational modification that controls functions of a wide collection of proteins and biological processes. Hence, given its pleiotropic role, viruses have developed many approaches to usurp SUMO conjugation to exploit the cellular host environment for their own benefit. Consistently, cancer cells also frequently impact on SUMO to force cellular transformation, underlining the importance of SUMO in health and diseases. Therefore, after a brief introduction to the multistep SUMOylation pathway, in this review we will focus our attention on several examples of strategies adopted by oncogenic viruses to hijack SUMOylation in order to promote infection, persistence and malignant transformation of host cells.
UR - http://www.scopus.com/inward/record.url?scp=85075499840&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85075499840&partnerID=8YFLogxK
U2 - 10.21775/cimb.035.001
DO - 10.21775/cimb.035.001
M3 - Article
C2 - 31422930
AN - SCOPUS:85075499840
VL - 35
SP - 1
EP - 16
JO - Current Issues in Molecular Biology
JF - Current Issues in Molecular Biology
SN - 1467-3037
ER -