Recent highlights: Onco viral exploitation of the sumo system

Domenico Mattoscio, Alessandro Medda, Susanna Chiocca

Research output: Contribution to journalArticlepeer-review

Abstract

Small ubiquitin-like modifier (SUMO)ylation is a crucial post-translational modification that controls functions of a wide collection of proteins and biological processes. Hence, given its pleiotropic role, viruses have developed many approaches to usurp SUMO conjugation to exploit the cellular host environment for their own benefit. Consistently, cancer cells also frequently impact on SUMO to force cellular transformation, underlining the importance of SUMO in health and diseases. Therefore, after a brief introduction to the multistep SUMOylation pathway, in this review we will focus our attention on several examples of strategies adopted by oncogenic viruses to hijack SUMOylation in order to promote infection, persistence and malignant transformation of host cells.

Original languageEnglish
Pages (from-to)1-16
Number of pages16
JournalCurrent Issues in Molecular Biology
Volume35
DOIs
Publication statusPublished - Jan 1 2020

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology
  • Microbiology (medical)

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