Recent insights and novel bioinformatics tools to understand the role of MicroRNAs binding to 5' untranslated region

Letizia da Sacco, Andrea Masotti

Research output: Contribution to journalArticlepeer-review

Abstract

MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression through the binding of the 3' untranslated region (3'UTR) of specific mRNAs. MiRNAs are post-transcriptional regulators and determine the repression of translation processes or the degradation of mRNA targets. Recently, another kind of miRNA-mediated regulation of translation (repression or activation) involving the binding of miRNA to the 5'UTR of target gene has been reported. The possible interactions and the mechanism of action have been reported in many works that we reviewed here. Moreover, we discussed also the available bioinformatics tools for predicting the miRNA binding sites in the 5'UTR and public databases collecting this information.

Original languageEnglish
Pages (from-to)480-495
Number of pages16
JournalInternational Journal of Molecular Sciences
Volume14
Issue number1
DOIs
Publication statusPublished - Jan 2013

Keywords

  • 3'UTR
  • 5'UTR
  • Bioinformatics tools
  • MiRNAs
  • Translation regulation

ASJC Scopus subject areas

  • Computer Science Applications
  • Molecular Biology
  • Catalysis
  • Inorganic Chemistry
  • Spectroscopy
  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Medicine(all)

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