Recenti acquisizioni sulla patogenesi dei sintomi addominali nei disordini funzionali intestinali

Translated title of the contribution: Recent insights into the pathogenesis of abdominal symptoms in functional bowel disorders

Elisabetta Cervio, Mariangela Rondanelli, Barbara Balestra, Antonio Dellabianca, Alessandro Agazzi, Attilio Giacosa, Marcello Tonini

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

In the gut, 5-HT acts as a paracrine signalling molecule released by enterochromaffin cells and as a transmitter released by some descending serotonergic interneurons. It has a prominent role in the regulation of motility, vascular tone, secretion and perception both in normal and under certain pathophysiological conditions, such as the carcinoid syndrome and the irritable bowel syndrome (IBS). Serotonin is known to markedly influence bowel function by activating at least five receptor types (5-HT1,2,3,4,7). Among all 5-HT receptors, those belonging to the 5-HT3 (a ionotropic receptor) and 5-HT4 (a metabotropic receptor) type are the most extensively studied in gastroenterology, resulting in commercially available (although not worldwide) serotonergic agents for the treatment of IBS and functional dyspepsia. Recently, 5-HT7 receptors have been found to participate in the accommodation process of the circular muscle during the preparatory phase of ileal peristalsis. Since an exaggerated accommodation of the gut wall may contribute to abdominal distension and bloating, 5-HT 7 receptor ligands may offer innovative opportunities for the pharmacological treatment of functional bowel disorders.

Original languageItalian
Pages (from-to)69-73
Number of pages5
JournalRecenti Progressi in Medicina
Volume98
Issue number2
Publication statusPublished - Feb 2007

Fingerprint

Irritable Bowel Syndrome
Serotonin Receptors
Serotonin
Serotonin 5-HT1 Receptors
Receptors, Serotonin, 5-HT4
Paracrine Communication
Enterochromaffin Cells
Serotonin Agents
Peristalsis
Dyspepsia
Carcinoid Tumor
Interneurons
Gastroenterology
Blood Vessels
Pharmacology
Ligands
Muscles
Therapeutics
serotonin 7 receptor

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Cervio, E., Rondanelli, M., Balestra, B., Dellabianca, A., Agazzi, A., Giacosa, A., & Tonini, M. (2007). Recenti acquisizioni sulla patogenesi dei sintomi addominali nei disordini funzionali intestinali. Recenti Progressi in Medicina, 98(2), 69-73.

Recenti acquisizioni sulla patogenesi dei sintomi addominali nei disordini funzionali intestinali. / Cervio, Elisabetta; Rondanelli, Mariangela; Balestra, Barbara; Dellabianca, Antonio; Agazzi, Alessandro; Giacosa, Attilio; Tonini, Marcello.

In: Recenti Progressi in Medicina, Vol. 98, No. 2, 02.2007, p. 69-73.

Research output: Contribution to journalArticle

Cervio, E, Rondanelli, M, Balestra, B, Dellabianca, A, Agazzi, A, Giacosa, A & Tonini, M 2007, 'Recenti acquisizioni sulla patogenesi dei sintomi addominali nei disordini funzionali intestinali', Recenti Progressi in Medicina, vol. 98, no. 2, pp. 69-73.
Cervio E, Rondanelli M, Balestra B, Dellabianca A, Agazzi A, Giacosa A et al. Recenti acquisizioni sulla patogenesi dei sintomi addominali nei disordini funzionali intestinali. Recenti Progressi in Medicina. 2007 Feb;98(2):69-73.
Cervio, Elisabetta ; Rondanelli, Mariangela ; Balestra, Barbara ; Dellabianca, Antonio ; Agazzi, Alessandro ; Giacosa, Attilio ; Tonini, Marcello. / Recenti acquisizioni sulla patogenesi dei sintomi addominali nei disordini funzionali intestinali. In: Recenti Progressi in Medicina. 2007 ; Vol. 98, No. 2. pp. 69-73.
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