Recenti acquisizioni sulla patogenesi dei sintomi addominali nei disordini funzionali intestinali

Translated title of the contribution: Recent insights into the pathogenesis of abdominal symptoms in functional bowel disorders

Elisabetta Cervio, Mariangela Rondanelli, Barbara Balestra, Antonio Dellabianca, Alessandro Agazzi, Attilio Giacosa, Marcello Tonini

Research output: Contribution to journalArticle

Abstract

In the gut, 5-HT acts as a paracrine signalling molecule released by enterochromaffin cells and as a transmitter released by some descending serotonergic interneurons. It has a prominent role in the regulation of motility, vascular tone, secretion and perception both in normal and under certain pathophysiological conditions, such as the carcinoid syndrome and the irritable bowel syndrome (IBS). Serotonin is known to markedly influence bowel function by activating at least five receptor types (5-HT1,2,3,4,7). Among all 5-HT receptors, those belonging to the 5-HT3 (a ionotropic receptor) and 5-HT4 (a metabotropic receptor) type are the most extensively studied in gastroenterology, resulting in commercially available (although not worldwide) serotonergic agents for the treatment of IBS and functional dyspepsia. Recently, 5-HT7 receptors have been found to participate in the accommodation process of the circular muscle during the preparatory phase of ileal peristalsis. Since an exaggerated accommodation of the gut wall may contribute to abdominal distension and bloating, 5-HT 7 receptor ligands may offer innovative opportunities for the pharmacological treatment of functional bowel disorders.

Translated title of the contributionRecent insights into the pathogenesis of abdominal symptoms in functional bowel disorders
Original languageItalian
Pages (from-to)69-73
Number of pages5
JournalRecenti Progressi in Medicina
Volume98
Issue number2
Publication statusPublished - Feb 2007

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Cervio, E., Rondanelli, M., Balestra, B., Dellabianca, A., Agazzi, A., Giacosa, A., & Tonini, M. (2007). Recenti acquisizioni sulla patogenesi dei sintomi addominali nei disordini funzionali intestinali. Recenti Progressi in Medicina, 98(2), 69-73.