Recent issues on dosimetry and radiobiology for peptide receptor radionuclide therapy

Research output: Contribution to journalArticle

Abstract

Peptide receptor radionuclide therapy (PRRT) has been constantly evolving over the last decade, providing successful results in the treatment of tumors expressing somatostatin receptors, especially with 90Y - and 177Lu - radiolabeled peptides. Recent and/ or ongoing studies assure new perspectives to come. Dosimetry represents a precious guide for the selection of radionuclides and peptides, for protocol settings, for toxicity prevention and therapy optimization. Thus, reliable and personalized dosimetry is more and more requested. This paper reviews the important advances recently obtained in the dosimetric methods that have been applied to this therapy. Special emphasis has been given to the impact derived (or derivable in the next future) from more refined dose evaluations focused on the kidneys and the red marrow. The possibility of improving the accuracy of dosimetry represents a further challenge for this therapy. Following the preliminary correlation observed between the biological effective dose and the probability of renal injury, more reliable dose estimates could definitively enhance the predicitivity of the radiobiological effects, for toxicity prevention as well as for tumor control.

Original languageEnglish
Pages (from-to)155-167
Number of pages13
JournalQuarterly Journal of Nuclear Medicine and Molecular Imaging
Volume55
Issue number2
Publication statusPublished - Apr 2011

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Radiobiology
Peptide Receptors
Radioisotopes
Kidney
Somatostatin Receptors
Peptides
Therapeutics
Neoplasms
Bone Marrow
Wounds and Injuries

Keywords

  • Biological
  • Dosimetry - Receptors
  • Peptide - Models

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

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title = "Recent issues on dosimetry and radiobiology for peptide receptor radionuclide therapy",
abstract = "Peptide receptor radionuclide therapy (PRRT) has been constantly evolving over the last decade, providing successful results in the treatment of tumors expressing somatostatin receptors, especially with 90Y - and 177Lu - radiolabeled peptides. Recent and/ or ongoing studies assure new perspectives to come. Dosimetry represents a precious guide for the selection of radionuclides and peptides, for protocol settings, for toxicity prevention and therapy optimization. Thus, reliable and personalized dosimetry is more and more requested. This paper reviews the important advances recently obtained in the dosimetric methods that have been applied to this therapy. Special emphasis has been given to the impact derived (or derivable in the next future) from more refined dose evaluations focused on the kidneys and the red marrow. The possibility of improving the accuracy of dosimetry represents a further challenge for this therapy. Following the preliminary correlation observed between the biological effective dose and the probability of renal injury, more reliable dose estimates could definitively enhance the predicitivity of the radiobiological effects, for toxicity prevention as well as for tumor control.",
keywords = "Biological, Dosimetry - Receptors, Peptide - Models",
author = "M. Cremonesi and M. Ferrari and {Di Dia}, A. and F. Botta and {De Cicco}, C. and L. Bodei and G. Paganelli",
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AU - Cremonesi, M.

AU - Ferrari, M.

AU - Di Dia, A.

AU - Botta, F.

AU - De Cicco, C.

AU - Bodei, L.

AU - Paganelli, G.

PY - 2011/4

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N2 - Peptide receptor radionuclide therapy (PRRT) has been constantly evolving over the last decade, providing successful results in the treatment of tumors expressing somatostatin receptors, especially with 90Y - and 177Lu - radiolabeled peptides. Recent and/ or ongoing studies assure new perspectives to come. Dosimetry represents a precious guide for the selection of radionuclides and peptides, for protocol settings, for toxicity prevention and therapy optimization. Thus, reliable and personalized dosimetry is more and more requested. This paper reviews the important advances recently obtained in the dosimetric methods that have been applied to this therapy. Special emphasis has been given to the impact derived (or derivable in the next future) from more refined dose evaluations focused on the kidneys and the red marrow. The possibility of improving the accuracy of dosimetry represents a further challenge for this therapy. Following the preliminary correlation observed between the biological effective dose and the probability of renal injury, more reliable dose estimates could definitively enhance the predicitivity of the radiobiological effects, for toxicity prevention as well as for tumor control.

AB - Peptide receptor radionuclide therapy (PRRT) has been constantly evolving over the last decade, providing successful results in the treatment of tumors expressing somatostatin receptors, especially with 90Y - and 177Lu - radiolabeled peptides. Recent and/ or ongoing studies assure new perspectives to come. Dosimetry represents a precious guide for the selection of radionuclides and peptides, for protocol settings, for toxicity prevention and therapy optimization. Thus, reliable and personalized dosimetry is more and more requested. This paper reviews the important advances recently obtained in the dosimetric methods that have been applied to this therapy. Special emphasis has been given to the impact derived (or derivable in the next future) from more refined dose evaluations focused on the kidneys and the red marrow. The possibility of improving the accuracy of dosimetry represents a further challenge for this therapy. Following the preliminary correlation observed between the biological effective dose and the probability of renal injury, more reliable dose estimates could definitively enhance the predicitivity of the radiobiological effects, for toxicity prevention as well as for tumor control.

KW - Biological

KW - Dosimetry - Receptors

KW - Peptide - Models

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