Recent understanding on diagnosis and management of central nervous system vasculitis in children

Ludovico Iannetti, Roberta Zito, Simone Bruschi, Laura Papetti, Fiorenza Ulgiati, Francesco Nicita, Francesca Del Balzo, Alberto Spalice

Research output: Contribution to journalArticle

Abstract

Central nervous system vasculitides in children may develop as a primary condition or secondary to an underlying systemic disease. Many vasculitides affect both adults and children, while some others occur almost exclusively in childhood. Patients usually present with systemic symptoms with single or multiorgan dysfunction. The involvement of central nervous system in childhood is not frequent and it occurs more often as a feature of subtypes like childhood polyarteritis nodosa, Kawasaki disease, Henoch Schönlein purpura, and Bechet disease. Primary angiitis of the central nervous system of childhood is a reversible cause of severe neurological impairment, including acute ischemic stroke, intractable seizures, and cognitive decline. The first line therapy of CNS vasculitides is mainly based on corticosteroids and immunosuppressor drugs. Other strategies include plasmapheresis, immunoglobulins, and biologic drugs. This paper discusses on current understanding of most frequent primary and secondary central nervous system vasculitides in children including a tailored-diagnostic approach and new evidence regarding treatment.

Original languageEnglish
Article number698327
JournalClinical and Developmental Immunology
Volume2012
DOIs
Publication statusPublished - 2012

Fingerprint

Central Nervous System Vasculitis
Schoenlein-Henoch Purpura
Polyarteritis Nodosa
Mucocutaneous Lymph Node Syndrome
Plasmapheresis
Vasculitis
Pharmaceutical Preparations
Immunoglobulins
Adrenal Cortex Hormones
Seizures
Central Nervous System
Stroke
Therapeutics

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Medicine(all)

Cite this

Recent understanding on diagnosis and management of central nervous system vasculitis in children. / Iannetti, Ludovico; Zito, Roberta; Bruschi, Simone; Papetti, Laura; Ulgiati, Fiorenza; Nicita, Francesco; Del Balzo, Francesca; Spalice, Alberto.

In: Clinical and Developmental Immunology, Vol. 2012, 698327, 2012.

Research output: Contribution to journalArticle

Iannetti, Ludovico ; Zito, Roberta ; Bruschi, Simone ; Papetti, Laura ; Ulgiati, Fiorenza ; Nicita, Francesco ; Del Balzo, Francesca ; Spalice, Alberto. / Recent understanding on diagnosis and management of central nervous system vasculitis in children. In: Clinical and Developmental Immunology. 2012 ; Vol. 2012.
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