Recently discovered adipokines and cardio-metabolic comorbidities in childhood obesity

Gloria Maria Barraco, Rosa Luciano, Michela Semeraro, Pedro L. Prieto-Hontoria, Melania Manco

Research output: Contribution to journalArticlepeer-review

Abstract

White adipose tissue (WAT) asset, in terms of cell number, fat storage capacity and endocrine function, is largely determined in early stages of life and is pivotal for shaping the WAT pro-inflammatory behavior. WAT derived adipokines have been shown to play a main role in several cardio-metabolic abnormalities of obesity. This review focuses on the most recently identified adipokines, namely adipocyte-fatty acid-binding protein, chemerin, fibroblast growth factor-21, lipocalin-2, omentin-1 and vaspin; their role in the pathogenesis of obesity and associated cardio-metabolic abnormalities; and on their adaptive response to body weight change. Evidence consistently suggests a pathogenic role for A-FABP, chemerin and FGF-21. Nevertheless, large population studies are needed to verify whether they can be useful to predict the risk of cardio-metabolic abnormalities in adulthood and/or monitor the clinical response to therapeutic interventions.

Original languageEnglish
Pages (from-to)19760-19776
Number of pages17
JournalInternational Journal of Molecular Sciences
Volume15
Issue number11
DOIs
Publication statusPublished - Oct 29 2014

Keywords

  • Adipokines
  • Adipose tissue
  • Cardiovascular disease
  • Childhood obesity
  • Inflammation
  • Metabolic syndrome

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Spectroscopy
  • Inorganic Chemistry
  • Catalysis
  • Molecular Biology
  • Computer Science Applications

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