Assetto recettoriale del carcinoma mammario primitivo e della metastasi linfonodale sincrona: studio istochimico.

Translated title of the contribution: Receptor assessment of primary breast carcinoma and synchronous metastatic lymph nodes: histochemical study

G. Simone, A. Paradiso, A. Barletta, E. Bellomo, M. Caponio, M. G. Sapia, G. Rella, S. Tommasi

Research output: Contribution to journalArticlepeer-review

Abstract

Several AA, utilizing the biochemical method (DCC) showed the presence or absence of hormonal receptor in either synchronous or metachronous metastatic nodes (N) can reproduce the receptor assessment (AR) of the primary breast tumor (T). We evaluated the AR in T and in synchronous N, by using two morphological methods, immunocytochemical and histofluorescent, to detect the nuclear Estrogen Receptor (ER1) and cytoplasmic sites of the II type (ER2 and PgR2). We studied 50 patients who underwent radical mastectomy for breast cancer N+. In this series we founded a high correlation between AR in T and in N: 82% for ER1, 94% for ER2, and 92% for PgR2. Also we observed 4 cases (2 ER1 and 2 PgR2) which presented the receptor in N only. These data are comparable to results obtained with the DCC method and confirm the opportunity to perform also morphological techniques to evaluate AR in breast cancer to take into consideration also cellularity and tumor heterogeneity informations.

Translated title of the contributionReceptor assessment of primary breast carcinoma and synchronous metastatic lymph nodes: histochemical study
Original languageItalian
Pages (from-to)45-53
Number of pages9
JournalPathologica
Volume83
Issue number1083
Publication statusPublished - Jan 1991

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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